Trial reportThe British journal of ophthalmology1997
Reproducibility and sensitivity of scanning laser Doppler flowmetry during graded changes in PO2.
Trial report in The British journal of ophthalmology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Effect of ischemic preconditioning on microvascular post-occlusive hyperemic reactions and quadriceps morphology in MMA: a randomized clinical trial.European journal of applied physiology · 2026Trial
- The additive effect of dorzolamide hydrochloride (Trusopt) and a morning dose of bimatoprost (Lumigan) on intraocular pressure and retrobulbar blood flow in patients with primary open-angle glaucoma.The British journal of ophthalmology · 2010Trial
- Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.The British journal of ophthalmology · 2005Trial
- Ocular haemodynamic responses to induced hypercapnia and hyperoxia in glaucoma.The British journal of ophthalmology · 2004Trial
- Peripapillary retinal blood flow in normal tension glaucoma.The British journal of ophthalmology · 1999Trial
- Variable Temporal Interval OCTA Velocimetry Enables Wide-Range Hemodynamic Mapping in Hyperoxia Models.Investigative ophthalmology & visual science · 2026Article
- Methods to measure blood flow and vascular reactivity in the retina.Frontiers in medicine · 2022Review
- Effects of Local Anesthetics With Vasoconstrictors on Dental Pulp Blood Flow and Oxygen Tension.Anesthesia progress · 2021Article
- Retinal Blood Velocity Waveform Characteristics With Aging and Arterial Stiffening in Hypertensive and Normotensive Subjects.Translational vision science & technology · 2021Article
- Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches.International journal of molecular sciences · 2021Review
- Different lasers reveal different skin microcirculatory flowmotion - data from the wavelet transform analysis of human hindlimb perfusion.Scientific reports · 2019Article
- A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.Frontiers in neuroscience · 2019Article
- Visualizing the vasculature of the entire human eye posterior hemisphere without a contrast agent.Biomedical optics express · 2019Article
- OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.Ophthalmology. Retina · 2018Article
- Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia.Investigative ophthalmology & visual science · 2015Article
- Inner retinal oxygen delivery and metabolism under normoxia and hypoxia in rat.Investigative ophthalmology & visual science · 2013Article
- Inner retinal oxygen extraction fraction in rat.Investigative ophthalmology & visual science · 2013Article
- Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography.PloS one · 2013Article
- MRI reveals differential regulation of retinal and choroidal blood volumes in rat retina.NeuroImage · 2011Article
- Blood flow magnetic resonance imaging of retinal degeneration.Investigative ophthalmology & visual science · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
backgroundRecently a commercially available scanning laser Doppler flowmeter has been produced, which provides two dimensional maps of the retinal perfusion. The aim of the present study was to investigate the reproducibility and the sensitivity of these measurements.
methods16 healthy subjects were randomised to inhale different gas mixtures of oxygen and nitrogen in a double blind crossover study. The following gas mixtures of oxygen and nitrogen were administered: 100% oxygen + 0% nitrogen, 80% oxygen + 20% nitrogen, 60% oxygen + 40% nitrogen, 40% oxygen + 60% nitrogen, 30% oxygen + 70% nitrogen, 20% oxygen + 80% nitrogen, 15% oxygen + 85% nitrogen, and 10% oxygen + 90% nitrogen. Retinal haemodynamic variables and systemic haemodynamics were measured during all inhalation periods. Recordings under resting conditions were performed three times to calculate intraclass coefficients.
resultsIn two subjects we did not obtain technically adequate results. A dose dependent change in retinal blood flow during graded oxygen breathing was observed (p < 0.001). During 100% oxygen breathing blood flow decrease was between 29% and 33%, whereas blood flow increase was between 28% and 33% during inhalation of 10% oxygen + 90% nitrogen.
conclusionsScanning laser Doppler flowmetry has an acceptable reproducibility and is appropriate for description of the effect of graded changes in PO2 on retinal haemodynamics. The main problems with the system are the large zero offset, the fixation during retinal scanning, and the neglect of blood flow changes during the cardiac cycle.
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