ArticleProceedings. Biological sciences1997
Mixed-genotype infections of malaria parasites: within-host dynamics and transmission success of competing clones.
Article in Proceedings. Biological sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Methods for Detecting Mycobacterial Mixed Strain Infections-A Systematic Review.Frontiers in genetics · 2020Pooled it
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- Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission.Nature communications · 2024Article
- Single-cell analyses of polyclonalResearch square · 2024Article
- InvestigatingMicrobiology spectrum · 2023Article
- Altered within- and between-host transmission under coinfection underpin parasite co-occurrence patterns in the wild.Evolutionary ecology · 2023Article
- Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites.The Journal of infectious diseases · 2022Article
- Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa.Malaria journal · 2021Article
- Article
- Competition Between Strains ofFrontiers in cellular and infection microbiology · 2019Article
- Globally invasive genotypes of the amphibian chytrid outcompete an enzootic lineage in coinfections.Proceedings. Biological sciences · 2018Article
- Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
- Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Higher Complexity of Infection and Genetic Diversity ofThe American journal of tropical medicine and hygiene · 2017Article
- Within-host competition between Borrelia afzelii ospC strains in wild hosts as revealed by massively parallel amplicon sequencing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Within-host competition does not select for virulence in malaria parasites; studies with Plasmodium yoelii.PLoS pathogens · 2015Article
- Restriction of Francisella novicida genetic diversity during infection of the vector midgut.PLoS pathogens · 2014Article
- TcI/TcII co-infection can enhance Trypanosoma cruzi growth in Rhodnius prolixus.Parasites & vectors · 2014Article
- Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites.PLoS computational biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed-genotype infections of microparasites are common, but almost nothing is known about how competitive interactions within hosts affect the subsequent transmission success of individual genotypes. We investigated changes in the composition of mixed-genotype infections of the rodent malaria Plasmodium chabaudi clones CR and ER by monoclonal antibody analysis of the asexual infection in mice, and by PCR amplification of clone-specific alleles in oocysts sampled from mosquitoes which had fed on these mice. Mixed-clone infections were initiated with a 9:1 ratio of the two clones, with ER as the minority in the first experiment and CR as the minority in the second experiment. When beginning as the majority, clones achieved parasite densities in mice comparable to those achieved in control (single-clone) infections. When they began as the minority, clones were suppressed to less than 10% of control parasitaemias during the early part of the infections. However, in mosquitoes, the frequency of the initially rare clone was substantially greater than it was in mice at the start of the infection or four days prior to the feed. In both experiments, the minority clone in the inocula produced as many, or more, oocysts than it did as a single-clone infection. These experiments show that asexual dominance during most of the infection is poorly correlated to transmission probability, and therefore that the assumption that within-host population size correlates to transmission probability may not be warranted. They also raise the fundamental question of why transmission rates of individual genotypes are often higher from mixed than single-clone infections.
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