ArticleThe Biochemical journal1997
Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Unveiling the Movement of RanBP1 During the Cell Cycle and Its Interaction with a Cyclin-Dependent Kinase (CDK) in Plants.International journal of molecular sciences · 2024Article
- RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases.Cancers · 2023Review
- Pan-Cancer Analysis Reveals the Prognostic Potential of the THAP9/THAP9-AS1 Sense-Antisense Gene Pair in Human Cancers.Non-coding RNA · 2022Article
- RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin.Nature communications · 2021Article
- FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.Nucleic acids research · 2019Article
- Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Functional characterization of open chromatin in bidirectional promoters of rice.Scientific reports · 2016Article
- Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development.Progress in neurobiology · 2015Review
- Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin.Frontiers in immunology · 2014Article
- Identification of regulatory regions of bidirectional genes in cervical cancer.BMC medical genomics · 2013Article
- Induction of Ran GTP drives ciliogenesis.Molecular biology of the cell · 2011Article
- Functional consequences of bidirectional promoters.Trends in genetics : TIG · 2011Review
- Three phases of DiGeorge/22q11 deletion syndrome pathogenesis during brain development: patterning, proliferation, and mitochondrial functions of 22q11 genes.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Review
- Dual transgene expression by foamy virus vectors carrying an endogenous bidirectional promoter.Gene therapy · 2010Article
- Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Searching for bidirectional promoters in Arabidopsis thaliana.BMC bioinformatics · 2009Article
- Silencing of endo-exonuclease expression sensitizes mouse B16F10 melanoma cells to DNA damaging agents.Investigational new drugs · 2007Article
- Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance.PLoS computational biology · 2006Article
- BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate.Molecular and cellular biology · 2006Article
- An abundance of bidirectional promoters in the human genome.Genome research · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine Htf9-a/RanBP1 and Htf9-c genes are divergently transcribed from a bidirectional promoter. The Htf9-a gene encodes the RanBP1 protein, a major partner of the Ran GTPase. The divergently transcribed Htf9-c gene encodes a protein sharing similarity with yeast and bacterial nucleic acid-modifying enzymes. We report here that both mRNA species produced by the Htf9-associated genes are regulated during the cell cycle progression, peak in S phase and decrease during mitosis. Transient expression experiments with reporter constructs showed that cell cycle expression is controlled at the transcriptional level, because the bidirectional Htf9 promoter is down-regulated in growth-arrested cells, is activated at the G1/S transition and reaches maximal activity in S phase, though with a different efficiency for each orientation. We have delimited specific promoter regions controlling S phase activity in one or both orientations: identified elements contain recognition sites for members belonging to both the E2F and Sp1 families of transcription factors. Together, the results suggest that the sharing of the regulatory region supports co-regulation of the Htf9-a/RanBP1 and Htf9-c genes in a common window of the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.