ArticleJournal of virology1997
Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Could CD4 capture by CD8+ T cells play a role in HIV spreading?Journal of biomedicine & biotechnology · 2010Article
- In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1.The open medical informatics journal · 2010Article
- Primary cell model for activation-inducible human immunodeficiency virus.Journal of virology · 2007Article
- Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo.Journal of virology · 2007Review
- Longitudinal assessment of de novo T cell production in relation to HIV-associated T cell homeostasis failure.AIDS research and human retroviruses · 2006Article
- Rapid expression of human immunodeficiency virus following activation of latently infected cells.Journal of virology · 2006Article
- CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- HIV-1 replication and pathogenesis in the human thymus.Current HIV research · 2003Review
- Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants.Journal of virology · 2002Article
- Effect of latent human immunodeficiency virus infection on cell surface phenotype.Journal of virology · 2002Article
- Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous.Journal of virology · 2002Article
- Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1.Journal of virology · 2001Article
- Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals.Journal of virology · 2001Article
- Infection of the CD45RA+ (naive) subset of peripheral CD8+ lymphocytes by human immunodeficiency virus type 1 in vivo.Journal of virology · 2001Article
- T cell signaling mechanisms that regulate HIV-1 infection.Immunologic research · 2001Article
- In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.Journal of virology · 1999Article
- High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.Journal of virology · 1999Article
- Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.Journal of virology · 1998Article
- Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Human immunodeficiency virus (HIV) infection of the thymus could have profound effects on development of the immune response, particularly in children. We and others have established that in addition to infecting and depleting CD4-bearing thymocytes, functional HIV proviruses are found in thymocytes lacking surface CD4 expression. Using in vitro thymocyte cultures, we show that neither HIV-mediated down regulation of CD4 nor CD4-independent infection contributes to the localization of HIV in cells lacking the primary virus receptor. Rather, infection of a CD4-positive precursor cell (CD4 positive/CD8 positive) with subsequent differentiation into a mature CD4-negative phenotype results in productively infected CD4-negative cells. This novel mechanism may contribute to pathogenesis by distributing viral sequences into functional subsets of T cells typically refractory to HIV infection and could account for the presence of viral DNA in CD8-positive lymphocytes recently observed in patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.