ArticleProceedings of the National Academy of Sciences of the United States of America1997
Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach.Insect molecular biology · 2025Article
- Rapid Analysis of Seven Polyamines inJournal of analytical methods in chemistry · 2024Article
- Bacterial challenge-associated metabolic phenotypes in Hermetia illucens defining nutritional and functional benefits.Scientific reports · 2021Article
- Article
- Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women?Journal of assisted reproduction and genetics · 2019Review
- Magnitude Assessment of Adult Neurogenesis in theFrontiers in physiology · 2018Article
- The role of polyamines in protein-dependent hypoxic tolerance of Drosophila.BMC physiology · 2008Article
- The making of a social insect: developmental architectures of social design.BioEssays : news and reviews in molecular, cellular and developmental biology · 2007Review
- Putrescine analogue cytotoxicity against Trypanosoma cruzi.Parasitology research · 2006Article
- Reproductive ground plan may mediate colony-level selection effects on individual foraging behavior in honey bees.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Immunocytochemical mapping of an RDL-like GABA receptor subunit and of GABA in brain structures related to learning and memory in the cricket Acheta domesticus.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent neurogenesis in an adult insect brain was recently shown to be stimulated by juvenile hormone (JH). This morphogenetic hormone was also shown to act on polyamine biosynthesis. To analyze the possible involvement of polyamines in the neurogenic action of JH, two series of experiments were carried out with adult female crickets, Acheta domesticus: (i) inhibition of the first key enzyme in polyamine biosynthesis, ornithine decarboxylase, with alpha-difluoromethylornithine (alpha-DFMO), and examination of the effects of this treatment on the neuroblast proliferation response to JH; and (ii) examination of the effects of putrescine supplementation on the mitotic index of JH-deprived and alpha-DFMO-treated females. In control females, alpha-DFMO treatment, as well as JH deprivation, greatly reduced neuroblast proliferation. Putrescine supplementation in alpha-DFMO-treated insects overcame the effects of alpha-DFMO, and allowed for detection of putrescine in the neural tissue and stimulation of brain neurogenesis. In JH-deprived females, alpha-DFMO treatment completely prevented the stimulatory action of JH on neuroblast proliferation and on brain putrescine levels. By contrast, putrescine feeding of JH-deprived animals was able to mimic the stimulatory effect of JH: brain putrescine levels increased and neuroblast proliferation was restored. To our knowledge, this report demonstrates for the first time that in vivo administration of putrescine can mimic the effects of a morphogenetic hormone on adult neuroblast proliferation, and shows the importance of polyamines, especially putrescine, in the transduction of JH message in neural tissue.
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Registered trials
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