ArticleProceedings of the National Academy of Sciences of the United States of America1997
Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Interaction of acetylcholinesterase with neurexin-1β regulates glutamatergic synaptic stability in hippocampal neurons.Molecular brain · 2014Article
- Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in ALS (G93A-SOD1) mice.BioMed research international · 2013Article
- beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC.PLoS pathogens · 2010Article
- Article
- Neurexin-neuroligin signaling in synapse development.Current opinion in neurobiology · 2007Review
- ARP, the cleavable C-terminal peptide of "readthrough" acetylcholinesterase, promotes neuronal development and plasticity.Journal of molecular neuroscience : MN · 2006Review
- Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoning.Environmental health perspectives · 2005Article
- Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology.The Journal of physiology · 2003Article
- Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase.Journal of molecular neuroscience : MN · 2002Article
- Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments.Molecular psychiatry · 2002Article
- Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase.Cellular and molecular neurobiology · 2001Article
- Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function.The Journal of cell biology · 1999Article
- Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic).American journal of human genetics · 1998Article
- Acetylcholinesterase enhances neurite growth and synapse development through alternative contributions of its hydrolytic capacity, core protein, and variable C termini.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Synaptogenesis and myopathy under acetylcholinesterase overexpression.Journal of molecular neuroscience : MNArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the possibility that overproduction of neuronal acetylcholinesterase (AChE) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal AChE overexpression in motoneurons and neuromuscular junctions of AChE-transgenic mice. Perikarya of spinal cord motoneurons were consistently enlarged from embryonic through adult stages in AChE-transgenic mice. Atypical motoneuron development was accompanied by premature enhancement in the embryonic spinal cord expression of choline acetyltransferase mRNA, encoding the acetylcholine-synthesizing enzyme choline acetyltransferase. In contrast, the mRNA encoding for neurexin-Ibeta, the heterophilic ligand of the AChE-homologous neuronal cell surface protein neuroligin, was drastically lower in embryonic transgenic spinal cord than in controls. Postnatal cessation of these dual transcriptional responses was followed by late-onset deterioration in neuromotor performance that was associated with gross aberrations in neuromuscular ultrastructure and with pronounced amyotrophy. These findings demonstrate embryonic feedback mechanisms to neuronal AChE overexpression that are attributable to both cholinergic and cell-cell interaction pathways, suggesting that embryonic neurexin Ibeta expression is concerted in vivo with AChE levels and indicating that postnatal changes in neuronal AChE-associated proteins may be involved in late-onset neuromotor pathologies.
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