ArticleProceedings of the National Academy of Sciences of the United States of America1997
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses.PloS one · 2019Article
- Article
- Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Promiscuous binding of extracellular peptides to cell surface class I MHC protein.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.PloS one · 2012Article
- Premature translational termination products are rapidly degraded substrates for MHC class I presentation.PloS one · 2012Article
- Burkitt lymphoma: pathogenesis and immune evasion.Journal of oncology · 2010Article
- A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.Eukaryotic cell · 2009Article
- Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA.Cancer immunology, immunotherapy : CII · 2007Article
- Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity.Molecular immunology · 2007Article
- Preventive and therapeutic vaccination with PAP-3, a novel human prostate cancer peptide, inhibits carcinoma development in HLA transgenic mice.Cancer immunology, immunotherapy : CII · 2007Article
- Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons.Journal of virology · 2005Article
- Identification of new MHC-restriction elements for presentation of the p210(BCR-ABL) fusion region to human cytotoxic T lymphocytes.Cancer immunology, immunotherapy : CII · 2003Article
- Intrasequence GFP in class I MHC molecules, a rigid probe for fluorescence anisotropy measurements of the membrane environment.Biophysical journal · 2003Article
- Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes.Gene therapy · 2001Article
- Alpha(1)-Antitrypsin Deficiency.Current treatment options in gastroenterology · 2000Article
- Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After brief incubation of cells with fluorescein-conjugated peptides that bind major histocompatibility complex (MHC) class I molecules, peptides were detected within the endoplasmic reticulum (ER) by microscopy or by binding to radiolabeled class I molecules. ER delivery of a nonfluorescent peptide was demonstrated using a mAb highly specific for the peptide-class I molecule complex. ER localization of peptides: (i) required expression of appropriate class I molecules in the ER but not on the cell surface, (ii) was diminished by expression of TAP, the MHC-encoded cytosol to ER peptide transporter, and (iii) was blocked by pinocytosis inhibitors but not by brefeldin A. These findings demonstrate the existence of a pathway, likely vesicular in nature, that conveys small extracellular substances to the ER without traversing the Golgi complex or the cytosol. This pathway contributes to the loading of exogenous peptides to MHC class I molecules, but its evolutionary significance may lie in other cellular processes, such as maintaining ER homeostasis or signaling by extracellular substances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.