ArticleProceedings of the National Academy of Sciences of the United States of America1997
An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 80 citations in OpenAlex.
- A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals.BMC genomics · 2018Article
- Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse.Fish & shellfish immunology · 2015Review
- Lipo-chitin oligosaccharides, plant symbiosis signalling molecules that modulate mammalian angiogenesis in vitro.PloS one · 2014Article
- The identification and characterization of chitotriosidase activity in pancreatin from porcine pancreas.Molecules (Basel, Switzerland) · 2013Article
- "Casting" light on the role of glycosylation during embryonic development: insights from zebrafish.Glycoconjugate journal · 2013Review
- Substrate promiscuity of N-acetylhexosamine 1-kinases.Molecules (Basel, Switzerland) · 2011Article
- N-acetylglucosamine: production and applications.Marine drugs · 2010Review
- Chitin research revisited.Marine drugs · 2010Review
- Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal muscle development.Glycoconjugate journal · 2009Article
- Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin.Biochemical and biophysical research communications · 2008Article
- CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The role of novel chitin-like polysaccharides in Alzheimer disease.Neurotoxicity research · 2007Review
- LysM receptors recognize friend and foe.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- CHRK1, a chitinase-related receptor-like kinase, plays a role in plant development and cytokinin homeostasis in tobacco.Plant molecular biology · 2003Article
- Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii.Biotechnology progressArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Derivatives of chitin oligosaccharides have been shown to play a role in plant organogenesis at nanomolar concentrations. Here we present data which indicate that chitin oligosaccharides are important for embryogenesis in vertebrates. We characterize chitin oligosaccharides synthesized in vitro by zebrafish and carp embryos in the late gastrulation stage by incorporation of radiolabeled N-acetyl-D-[U14C]glucosamine and by HPLC in combination with enzymatic conversion using the Bradyrhizobium NodZ alpha-1, 6-fucosyltransferase and chitinases. A rapid and sensitive bioassay for chitin oligosaccharides was also used employing suspension-cultured plant cells of Catharanthus roseus. We show that chitin oligosaccharide synthase activity is apparent only during late gastrulation and can be inhibited by antiserum raised against the Xenopus DG42 protein. The DG42 protein, a glycosyltransferase, is transiently expressed between midblastula and neurulation in Xenopus and zebrafish embryogenesis. Microinjection of the DG42 antiserum or the Bradyrhizobium NodZ enzyme in fertilized eggs of zebrafish led to severe defects in trunk and tail development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.