ArticleProceedings of the National Academy of Sciences of the United States of America1997
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 97 citations in OpenAlex.
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- GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development.Advances in experimental medicine and biology · 2024Review
- Preclinical studies on the use of a P-selectin-blocking monoclonal antibody to halt progression of myelofibrosis in the Gata1Experimental hematology · 2023Article
- E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates.Science immunology · 2021Article
- Novel targets to cure primary myelofibrosis from studies on Gata1IUBMB life · 2020Review
- DivergentBiology open · 2018Article
- Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Epigenetic and genetic mechanisms in red cell biology.Current opinion in hematology · 2014Review
- Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis.Platelets · 2014Article
- Preclinical models for drug selection in myeloproliferative neoplasms.Current hematologic malignancy reports · 2013Review
- Identification of biologically relevant enhancers in human erythroid cells.The Journal of biological chemistry · 2013Article
- Regulation of GATA factor expression is distinct between erythroid and mast cell lineages.Molecular and cellular biology · 2012Article
- Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis.Blood · 2012Article
- Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation.Molecular and cellular biology · 2012Article
- The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ.The EMBO journal · 2011Article
- Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression.Blood · 2010Article
- Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation.Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2010Article
- Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation.Molecular and cellular biology · 2009Article
- Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.The Journal of experimental medicine · 2008Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The transcription factor GATA-1, which is expressed in several hematopoietic lineages and multipotential progenitors, is required for the development of red blood cells and platelets. To identify control elements of the mouse GATA-1 gene, we analyzed DNase I hypersensitivity of the locus in erythroid chromatin and the expression of GATA-1/Escherichia coli beta-galactosidase (lacZ) transgenes in mice. Transgenes with 2.7 kb of promoter sequences are expressed infrequently and only within adult (definitive) erythroid cells. We show that inclusion of an upstream hypersensitive site (HS I) markedly enhances the frequency of expressing transgenic lines and activates expression in primitive erythroid cells. This pattern recapitulates the proper pattern of GATA-1 expression during development. By breeding a GATA-1/lacZ transgene into a GATA-1(-) background, we also have shown that the activation or maintenance of GATA-1 expression does not require the presence of GATA-1 itself, thereby excluding simple models of positive autoregulation. The transgene cassette reported here should be useful in directing expression of foreign sequences at the onset of hematopoiesis in the embryo and may assist in the identification of upstream regulators of the GATA-1 gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.