Evidence map›Paper›PMID 9223255›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1997

DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection.

R R Hudson, A G Sáez, F J Ayala

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 62 citations in OpenAlex.

  1. Footprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles.Proceedings of the National Academy of Sciences of the United States of America · 2020
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  11. Plasmodium vivax: recent world expansion and genetic identity to Plasmodium simium.Proceedings of the National Academy of Sciences of the United States of America · 2005
    Article
  12. Article
  13. Meager genetic variability of the human malaria agent Plasmodium vivax.Proceedings of the National Academy of Sciences of the United States of America · 2004
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  14. Article
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  17. Effects of inbreeding on the genetic diversity of populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2003
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

R R HudsonDepartment of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
A G Sáez
F J Ayala
University of California, Irvine · US

Funding

POPULATION GENETICS OF SOD, ADH, AND GPDHP01GM042397 · NIGMS · UNIVERSITY OF CALIFORNIA IRVINE · 1991 to 1995
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NIGMS NIH HHS GM042397
6 · The paper itself

Abstract

Patterns of variation at the Sod locus of Drosophila melanogaster suggest that the protein polymorphism at this locus has very recently arisen. In addition, it appears that a previously rare DNA variant has been recently and rapidly driven to intermediate frequency. From the size of the region (>20 kb) that has been swept along with this rare variant, and patterns of linkage disequilibrium in the region, it is inferred that strength of selection was large (s > 0.01) and that the sweep occurred more than 25,000 generations ago. In addition, there are striking similarities to patterns of variation observed at the Est6 and Est-P loci, which are located approximately 1,000 kb from Sod.

Indexed as

Polymorphism, GeneticSelection, GeneticAnimalsDNADrosophila melanogasterGenetic LinkageSequence Homology, Nucleic AcidSuperoxide DismutaseDNASuperoxide Dismutase

Identifiers

PMID9223255
PMCPMC33684
OpenAlexW2066182454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.