ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Direct recording of nicotinic responses in presynaptic nerve terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- Electrochemical Measurements of Acetylcholine-Stimulated Dopamine Release in Adult Drosophila melanogaster Brains.Analytical chemistry · 2018Article
- Nicotinic regulation of energy homeostasis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.British journal of pharmacology · 2012Article
- Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors.Current neuropharmacology · 2011Article
- Historical and current perspective on tobacco use and nicotine addiction.Trends in neurosciences · 2011Review
- Nicotine and behavioral sensitization.Journal of molecular neuroscience : MN · 2010Review
- Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: relevance to regulating alpha7-containing nicotinic receptors and synaptic function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat.The Journal of physiology · 2002Article
- The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo.The Journal of physiology · 2000Review
- Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Neuronal acetylcholine receptors with alpha7 subunits are concentrated on somatic spines for synaptic signaling in embryonic chick ciliary ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Nerve terminal currents induced by autoreception of acetylcholine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Nicotine selectively enhances NMDA receptor-mediated synaptic transmission during postnatal development in sensory neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Nicotine: abused substance and therapeutic agent.Journal of psychiatry & neuroscience : JPN · 1998Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nicotinic acetylcholine receptors are widely expressed in the nervous system, but their functions remain poorly understood. One attractive hypothesis is that the receptors act presynaptically to modulate synaptic transmission. We provide a direct demonstration of presynaptic nicotinic receptors in situ by using whole-cell patch-clamp techniques to record currents in large presynaptic calyces that midbrain neurons form on ciliary neurons. Bath application of nicotine induced inward currents in the calyces capable of generating action potentials that overrode the limited space clamp achievable. The inward currents reversed near 0 mV and showed inward rectification common for neuronal nicotinic receptors. Tetrodotoxin (TTX) blocked the action potentials but not the inward currents. alpha-Bungarotoxin blocked both, consistent with the presynaptic receptors containing alpha7 subunits. Recording from the postsynaptic ciliary neurons during nicotine exposure revealed EPSCs that TTX blocked, presumably by blocking presynaptic action potentials. The postsynaptic cells also displayed bimodal inward currents caused by their own nicotinic receptors; the bimodal currents were not blocked by TTX but were blocked partially by alpha-bungarotoxin and completely by D-tubocurarine. Dye-filling with Lucifer yellow from the recording pipette confirmed the identity of patched structures and showed no dye transfer between calyx and ciliary neuron. When calyces or ciliary neurons were labeled en mass with neurobiotin and biocytin through nerve roots, dye transfer was rarely observed. Thus, electrical synapses were infrequent and unlikely to influence calyx responses. Immunochemical analysis of preganglionic nerve extracts identified receptors that bind alpha-bungarotoxin and contain alpha7 subunits. The results unambiguously document the existence of functional presynaptic nicotinic receptors.
Indexed as
Identifiers
9221778PMC6573196W1596007902What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.