ArticleThe Journal of experimental medicine1997
Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Article
- NKT Cells in Mice Originate from Cytoplasmic CD3-Positive, CD4Scientific reports · 2019Article
- Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.Cold Spring Harbor perspectives in biology · 2018Review
- NF-κB Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death.Scientific reports · 2017Article
- Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.The Journal of experimental medicine · 2017Article
- Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective.Frontiers in immunology · 2017Review
- Regulation of NKT Cell Localization in Homeostasis and Infection.Frontiers in immunology · 2015Review
- Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling.European journal of immunology · 2013Article
- Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- IL-4 and IL-4 receptor expression is dispensable for the development and function of natural killer T cells.PloS one · 2013Article
- Article
- IL-15 regulates homeostasis and terminal maturation of NKT cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulation of natural killer T-cell development by deubiquitinase CYLD.The EMBO journal · 2010Article
- Natural killer T cell-a cat o' nine lives!The EMBO journal · 2010Article
- An overview of IL-7 biology and its use in immunotherapy.Journal of immunotoxicology · 2010Article
- Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia.Arthritis research & therapy · 2005Article
- Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.Immunology · 2003Review
- Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Immune recognition, response, and regulation: how T lymphocytes do it.Immunologic research · 2001Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The commitment, differentiation, and expansion of mainstream alpha/beta T cells during ontogeny depend on the highly controlled interplay of signals relayed by cytokines through their receptors on progenitor cells. The role of cytokines in the development of natural killer (NK)1(+) natural T cells is less clearly understood. In an approach to define the role of cytokines in the commitment, differentiation, and expansion of NK1(+) T cells, their development was studied in common cytokine receptor gamma chain (gammac) and interleukin (IL)-7 receptor alpha (IL-7Ralpha)-deficient mice. These mutations block mainstream alpha/beta T cell ontogeny at an early prethymocyte stage. Natural T cells do not develop in gammac-deficient mice; they are absent in the thymus and peripheral lymphoid organs such as the liver and the spleen. In contrast, NK1(+) T cells develop in IL-7Ralpha-deficient mice in the thymus, and they are present in the liver and in the spleen. However, the absolute number of NK1(+) T cells in the thymus of IL-7Ralpha-deficient mice is reduced to approximately 10%, compared to natural T cell number in the wild-type thymus. Additional data revealed that NK1(+) T cell ontogeny is not impaired in IL-2- or IL-4-deficient mice, suggesting that neither IL-2, IL-4, nor IL-7 are required for their development. From these data, we conclude that commitment and/or differentiation to the NK1(+) natural T cell lineage requires signal transduction through the gammac, and once committed, their expansion requires signals relayed through the IL-7Ralpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.