ArticleThe Journal of experimental medicine1997
Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The development of innate lymphoid cells.Nature immunology · 2026Review
- RAG recombinase expression discriminates the development of natural killer cells.Frontiers in immunology · 2025Article
- Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells.Bioactive materials · 2024Article
- Progress on methods of T lymphocyte developmentZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- The role of NK cells in fighting the virus infection and sepsis.International journal of medical sciences · 2021Review
- Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System.Biomedicines · 2020Article
- Human NK Cell Development: One Road or Many?Frontiers in immunology · 2019Review
- Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells.Stem cells international · 2016Article
- An in vitro model of innate lymphoid cell function and differentiation.Mucosal immunology · 2015Article
- Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength.European journal of immunology · 2014Article
- Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.Frontiers in immunology · 2014Review
- Hematopoietic progenitor cell lines with myeloid and lymphoid potential.Nature methods · 2013Article
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- Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.Stem cells (Dayton, Ohio) · 2011Article
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- The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors.European journal of immunology · 2010Article
- GATA-3 is required for early T lineage progenitor development.The Journal of experimental medicine · 2009Article
- Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.Stem cells (Dayton, Ohio) · 2009Article
- Hidden talents of natural killers: NK cells in innate and adaptive immunity.EMBO reports · 2009Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipotent progenitors for T and natural killer (NK) lymphocytes are thought to exist among early precursor thymocytes. The identification and functional properties of such a progenitor population remain undefined. We report the identification of a novel developmental stage during fetal thymic ontogeny that delineates a population of T/NK-committed progenitors (NK1. 1(+)/CD117(+)/CD44(+)/CD25(-)). Thymocytes at this stage in development are phenotypically and functionally distinguishable from the pool of multipotent lymphoid-restricted (B, T, and NK) precursor thymocytes. Exposure of multipotent precursor thymocytes or fetal liver- derived hematopoietic progenitors to thymic stroma induces differentiation to the bipotent developmental stage. Continued exposure to a thymic microenvironment results in predominant commitment to the T cell lineage, whereas coculture with a bone marrow-derived stromal cell line results in the generation of mature NK cells. Thus, the restriction point to T and NK lymphocyte destinies from a multipotent progenitor stage is marked by a thymus-induced differentiation step.
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