ArticleThe EMBO journal1997
Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 104 citations in OpenAlex.
- Dysregulation of HOXA genes in acute myeloid leukemia and targeted therapy.NPJ precision oncology · 2025Review
- Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel ROS1 fusion gene and PBX1 as prognostic marker.Clinical and translational medicine · 2024Article
- Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish.Nature communications · 2023Article
- Analysis of HOXB1 gene in a cohort of patients with sporadic ventricular septal defect.Molecular biology reports · 2018Article
- Alternative splicing links histone modifications to stem cell fate decision.Genome biology · 2018Article
- TALE factors use two distinct functional modes to control an essential zebrafish gene expression program.eLife · 2018Article
- The PBX1 lupus susceptibility gene regulates CD44 expression.Molecular immunology · 2017Article
- Article
- Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice.Clinical immunology (Orlando, Fla.) · 2015Article
- Transcriptional dynamics of homeobox C11 gene in water buffalo bubalus bubalis.DNA and cell biology · 2015Article
- A Simple Predictive Enhancer Syntax for Hindbrain Patterning Is Conserved in Vertebrate Genomes.PloS one · 2015Article
- Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice.Transgenic research · 2013Article
- Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.PloS one · 2013Article
- The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.Genes and immunity · 2012Article
- HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.American journal of human genetics · 2012Article
- Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.PloS one · 2012Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.Development (Cambridge, England) · 2010Article
- Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia.Journal of molecular medicine (Berlin, Germany) · 2010Article
- The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells.Journal of cellular biochemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hox genes control cell fates and specify regional identities in vertebrate development. Hox proteins show a relaxed DNA-binding selectivity in vitro, suggesting that functional specificity is achieved in vivo through the action of transcriptional co-factors. Pbx proteins are good candidates for such a role, on the basis of both genetic and biochemical evidence. We report that the human Pbx1 and HOXB1 proteins can cooperatively activate transcription through a genetically characterized Hox target, i.e. an autoregulatory element directing spatially restricted expression of the murine Hoxb-1 gene (b1-ARE) in the developing hindbrain. On the b1-ARE, only a restricted subset of HOX proteins (HOXA1, HOXB1, HOXA2) are able to bind cooperatively with Pbx1 and activate transcription. Selective recognition of the b1-ARE is mediated by the N-terminal region of the HOX homeodomain. The DNA-binding and protein-protein interaction functions of HOXB1 and Pbx1 are all necessary for the assembly of a transcriptionally active complex on the b1-ARE. Functional dissection of the complex allowed the localization of the main activation domain in the HOXB1 N-terminal region, and of an additional one in the C-terminal region of Pbx1 contained in the Pbx1a but not in the alternatively spliced Pbx1b isoform. Our results indicate that Pbx1 acts as a transcriptional co-factor of Hox proteins, allowing selective recognition and cooperative activation of regulatory target sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.