ArticleThe EMBO journal1997
Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 100 citations in OpenAlex.
- Article
- B cell receptor-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics.Journal of cell science · 2023Article
- Modular Polymer Antigens To Optimize Immunity.Biomacromolecules · 2019Article
- The regulators of BCR signaling during B cell activation.Blood science (Baltimore, Md.) · 2019Review
- Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses.Frontiers in immunology · 2019Review
- Multivalent Antigens for Promoting B and T Cell Activation.ACS chemical biology · 2015Article
- Review
- The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.Biochimica et biophysica acta · 2014Review
- Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling.ACS chemical biology · 2014Article
- Actin-mediated feedback loops in B-cell receptor signaling.Immunological reviews · 2013Review
- Article
- The cytoskeleton coordinates the early events of B-cell activation.Cold Spring Harbor perspectives in biology · 2011Review
- The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Immunity · 2010Article
- Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses.Traffic (Copenhagen, Denmark) · 2009Review
- Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.Molecular immunology · 2008Article
- The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.The Journal of cell biology · 2007Article
- Article
- B cell antigen receptor signaling and internalization are mutually exclusive events.PLoS biology · 2006Article
- Antigen binding to GM1 ganglioside results in delayed presentation: minimal effects of GM1 on presentation of antigens internalized via other pathways.Immunology · 2002Article
- Major histocompatibility complex class II presentation of cell-associated antigen is mediated by CD8alpha+ dendritic cells in vivo.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The B-cell antigen receptor (BCR) internalizes bound antigen such that antigen-derived peptides become associated with emigrating major histocompatibility complex (MHC) class II molecules for presentation to T cells. Experiments with B-cell transfectants reveal that BCR confers a specificity of intracellular targeting since chimeric antigen receptors which internalize antigen by virtue of a heterologous cytoplasmic domain do not necessarily give rise to presentation. In contrast, however, previous studies have shown that antigen binding to irrelevant cell surface molecules (e.g. transferrin receptor, MHC class I) can ultimately lead to presentation. The solution to this paradox appears to be that the intracellular targeting by BCR actually reflects an acceleration of antigen delivery. Depending on the nature of the BCR-antigen interaction, this accelerated targeting can be essential in determining whether or not internalization leads to significant presentation. Physiologically, the accelerated delivery of antigen by BCR could prove of particular importance early in the immune response when antigen-BCR interaction is likely to be poor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.