ArticleThe Journal of clinical investigation1997
Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 103 citations in OpenAlex.
- Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story.Medicinal research reviews · 2021Review
- Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.Pharmaceuticals (Basel, Switzerland) · 2017Review
- The danger from within: alarmins in arthritis.Nature reviews. Rheumatology · 2016Review
- HSP60: issues and insights on its therapeutic use as an immunoregulatory agent.Frontiers in immunology · 2011Article
- The involvement of heat-shock proteins in the pathogenesis of autoimmune arthritis: a critical appraisal.Seminars in arthritis and rheumatism · 2010Review
- Heat shock proteins in children and young adults on chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2009Article
- Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin.PLoS pathogens · 2009Review
- Heat-shock proteins can promote as well as regulate autoimmunity.Autoimmunity reviews · 2009Review
- Regulation of autoimmune arthritis by self-heat-shock proteins.Trends in immunology · 2008Article
- Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Diversity of physiological cell reactivity to heat shock protein 60 in different mouse strains.Cell stress & chaperones · 2007Article
- Heat shock proteins induce T cell regulation of chronic inflammation.Annals of the rheumatic diseases · 2006Review
- Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate.Annals of the rheumatic diseases · 2005Article
- Heat-shock proteins induce T-cell regulation of chronic inflammation.Nature reviews. Immunology · 2005Review
- Qa-1 restriction of CD8+ suppressor T cells.The Journal of clinical investigation · 2004Review
- Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy.Current rheumatology reports · 2002Review
- Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients.Infection and immunity · 2002Article
- Relationship between disease severity and responses by blood mononuclear cells from patients with rheumatoid arthritis to human heat-shock protein 60.Immunology · 2000Article
- Cytokines and the immunopathology of the spondyloarthropathies.Current rheumatology reports · 1999Review
- Role of heat shock proteins in protection from and pathogenesis of infectious diseases.Clinical microbiology reviews · 1999Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In several animal models of rheumatoid arthritis (RA), T cell responses to self 60-kD heat-shock protein 60 (hsp60) protect against the induction of arthritis. The nature of this suppressive T cell activity induced by self hsp60 is not clear. In the present study, T cell responses to human (self) hsp60 in RA in terms of type 1 (T1) and type 2 (T2) T cell activity were assessed. The results show that human and not bacterial hsp60-reactive synovial fluid (SF) T cells of patients with RA proliferate in the presence of the T2 cell growth factor IL-4. SF T cells stimulated with human hsp60 produced significantly lower amounts of IFN-gamma and higher amounts of IL-4 than SF T cells stimulated with bacterial hsp60 (P </= 0.002 and 0.05, respectively), and consequently a lower T1/T2 cell cytokine ratio was observed for human versus bacterial hsp60 (P </= 0.004). Additionally, human and not mycobacterial hsp60-specific T cell lines suppressed TNF-alpha production. Together, our results suggest that human hsp60, as overexpressed in inflamed synovium of patients with RA, can contribute to suppression of arthritis by the stimulation of regulatory suppressive T cell activity.
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