ArticleThe Journal of physiology1997
Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
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- Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation.Scientific reports · 2018Article
- Mammalian γ2 AMPK regulates intrinsic heart rate.Nature communications · 2017Article
- Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co-cultured with atrial myocytes.Experimental and therapeutic medicine · 2017Article
- Elementary functional properties of single HCN2 channels.Biophysical journal · 2013Article
- Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.The Journal of general physiology · 2010Article
- Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium.Heart rhythm · 2010Article
- Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach.Biophysical journal · 2008Article
- Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.The Journal of general physiology · 2006Article
- The action of prostaglandins on ion channels.Current neuropharmacology · 2006Article
- Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node.The Journal of physiology · 2003Article
- "Sleepy" inward rectifier channels in guinea-pig cardiomyocytes are activated only during strong hyperpolarization.The Journal of physiology · 2002Article
- Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes.The Journal of physiology · 2000Article
- Cyclic GMP-dependent but G-kinase-independent inhibition of Ca2+-dependent Cl- currents by NO donors in cat tracheal smooth muscle.The Journal of physiology · 1998Article
- Hyperpolarization-activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat.The Journal of physiology · 1998Article
- PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.Channels (Austin, Tex.)Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The action of the two diastereometric phosphorothioate derivatives of cAMP, Rp-cAMPs and Sp-cAMPs, was investigated on hyperpolarization-activated 'pacemaker' current (i(f)) recorded in inside-out macropatches from rabbit sino-atrial (SA) node myocytes. 2. When superfused on the intracellular side of f-channels at the concentration of 10 microM, both cAMP derivatives accelerated i(f) activation; their action was moderately less pronounced than that due to the same concentration of cAMP. 3. The measurement of the i(f) conductance-voltage relation by voltage ramp protocols indicated that both cAMP analogues shift the activation curve of i(f) to more positive voltages with no change in maximal (fully activated) conductance. 4. Dose-response relationships of the shift of the i(f) activation curve showed that both Rp-cAMPs and Sp-cAMPs act as agonists in the cAMP-dependent direct f-channel activation. Fitting data to the Hill equation resulted in maximal shifts of 9.6 and 9.5 mV, apparent dissociation constants of 0.82 and 5.4 microM, and Hill coefficients of 0.82 and 1.12 for Sp-cAMPs and Rp-cAMPs, respectively. 5. The activating action of Rp-cAMPs, a known antagonist of cAMP in the activation of cAMP-dependent protein kinase, confirms previously established evidence that f-channel activation does not involve phosphorylation. These results also suggest that the cAMP binding site of f-channels may be structurally similar to the cyclic nucleotide binding site of olfactory receptor channels.
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