ArticleThe Journal of physiology1997
Characterization of apical potassium channels induced in rat distal colon during potassium adaptation.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review.American journal of physiology. Cell physiology · 2021Pooled it
- Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- The LRRC family of BK channel regulatory subunits: potential roles in health and disease.The Journal of physiology · 2022Review
- Hyperkalemia in patients undergoing hemodialysis: Its pathophysiology and management.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2022Review
- Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Colonic Potassium Absorption and Secretion in Health and Disease.Comprehensive Physiology · 2018Review
- How Dangerous Is Hyperkalemia?Journal of the American Society of Nephrology : JASN · 2017Review
- Potassium Channelopathies and Gastrointestinal Ulceration.Gut and liver · 2016Review
- Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon.American journal of physiology. Cell physiology · 2012Article
- Aldosterone induces active K⁺ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon.American journal of physiology. Cell physiology · 2012Article
- The secretory KCa1.1 channel localises to crypts of distal mouse colon: functional and molecular evidence.Pflugers Archiv : European journal of physiology · 2011Article
- Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels.The Journal of physiology · 2010Article
- Colonic potassium handling.Pflugers Archiv : European journal of physiology · 2010Review
- Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion.The Journal of physiology · 2008Article
- Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.American journal of physiology. Renal physiology · 2008Article
- Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4.The Journal of physiology · 2007Article
- Pathways for K+ efflux in isolated surface and crypt colonic cells. Activation by calcium.The Journal of membrane biology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Chronic dietary K+ loading stimulates an active K+ secretory process in rat distal colon, which involves an increase in the macroscopic apical K+ conductance of surface epithelial cells. In the present study, the abundance and characteristics of K+ channels constituting this enhanced apical K+ conductance were evaluated using patch clamp recording techniques. 2. In isolated non-polarized surface cells, K+ channels were seen in 9 of 90 (10%) cell-attached patches in cells from control animals, and in 247 of 437 (57%) cell-attached patches in cells from K(+)-loaded animals, with a significant (P < 0.001) shift in distribution density. Similarly, recordings from cell-attached patches of the apical membrane of surface cells surrounding the openings of distal colonic crypts revealed identical K+ channels in 1 of 11 (9%) patches in control animals, and in 9 of 13 (69%) patches in K(+)-loaded animals. 3. In isolated surface cells and surface cells in situ, K+ channels had mean slope conductances of 209 +/- 6 and 233 +/- 14 pS, respectively, when inside-out patches were bathed symmetrically in K2SO4 solution. The channels were sensitive to 'cytosolic' Ca2+ concentration, were voltage sensitive at 'cytosolic' Ca2+ concentrations encountered in colonic epithelial cells, and were inhibited by 1 mM quinidine, 20 mM TEA or 5 mM Ba2+ ions. 4. The data show that dietary K+ loading increases the abundance of Ca(2+)- and voltage-sensitive large-conductance K+ channels in the apical membrane of surface cells in rat distal colon. These channels constitute the enhanced macroscopic apical K+ conductance previously identified in these cells, and are likely to play a critical role in the active K+ secretory process that typifies this model of colonic K+ adaptation.
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