ArticleGenetics1997
Genotype selection to rapidly breed congenic strains.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 30 citations in OpenAlex.
- Strain background determines lymphoma incidence in Atm knockout mice.Neoplasia (New York, N.Y.) · 2014Article
- The relevance of individual genetic background and its role in animal models of epilepsy.Epilepsy research · 2011Review
- Murine Prkdc polymorphisms impact DNA-PKcs function.Radiation research · 2011Article
- DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.Oncogene · 2008Article
- Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Review
- Selection in backcross programmes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway.Genes and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Congenic strains can now be constructed guided by the transmission of DNA markers. This allows not only selection for transmission of a desired, donor-derived differential region but also selection against the transmission of unwanted donor origin genomic material. The additional selection capacity should allow congenic strains to be produced in fewer generations than is possible with random backcrosses. Here, we consider modifications of a standard backcross breeding scheme to produce congenic mice by the inclusion of genotype-based selective breeding strategies. Simulation is used to evaluate the consequences of each strategy on the number of chromosomes that contain unwanted, donor-derived genetic material and the average length of this unwanted donor DNA for each backcross generation. Our prototypic strategy was to choose a single mouse to sire each generation using criteria designed to select against the transmission of chromosomes, other than the one containing the replacement genomic region, that contain any donor origin sequence at all. This chromosome elimination strategy resulted in an average of 16.4 chromosomes free of donor DNA in mice of the third backcross (N3) generation. A strategy based solely on positive selection for the replacement region required six backcross generations to achieve the same results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.