ArticleGenetics1997
A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Comparative gut proteomics study revealing adaptive physiology of Eurasian spruce bark beetle,Frontiers in plant science · 2023Article
- Specialization of theGenes & development · 2019Article
- UAP56 associates with DRM2 and is localized to chromatin in Arabidopsis.FEBS open bio · 2019Article
- Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin.Cell reports · 2018Article
- Adaptive Evolution Leads to Cross-Species Incompatibility in the piRNA Transposon Silencing Machinery.Developmental cell · 2017Article
- Article
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila.Genetics · 2016Article
- Article
- Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56.Molecular biology reports · 2012Article
- High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.Molecular and cellular biology · 2001Article
- Article
- Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers.Genetics · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, position-effect variegation of the white gene has been a useful phenomenon by which to study chromosome structure and the genes that modify it. We have identified a new enhancer of variegation locus, Dmrnahel (hel). Deletion of mutation of hel enhances white variegation, and this can be reversed by a transformed copy of hel+. In the presence of two endogenous copies, the transformed hel+ behaves as a suppressor of variegation. hel is an essential gene and functions both maternally and zygotically. The HEL protein is similar to known RNA helicases, but contains an unusual variant (DECD) of the DEAD motif common to these proteins. Potential HEL homologues have been found in mammals, yeast and worms. HEL protein associates with salivary gland chromosomes and locates to nuclei of embryos and ovaries, but disappears in mitotic domains of embryos as chromosomes condense. We propose that the HEL protein promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin, and that HEL is regulated by, and may have a role in, the mitotic cell cycle during embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.