ArticleGenetics1997
Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen.PLoS genetics · 2012Article
- Effects of chromosomal rearrangements on transvection at the yellow gene of Drosophila melanogaster.Genetics · 2009Article
- A genomewide survey argues that every zygotic gene product is dispensable for the initiation of somatic homolog pairing in Drosophila.Genetics · 2008Article
- Article
- Enhancer choice in cis and in trans in Drosophila melanogaster: role of the promoter.Genetics · 2004Article
- Enhancer action in trans is permitted throughout the Drosophila genome.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.Genes & development · 1999Article
- Article
- Dominant defects in Drosophila eye pigmentation resulting from a euchromatin-heterochromatin fusion gene.Genetics · 1998Article
- Two modes of transvection: enhancer action in trans and bypass of a chromatin insulator in cis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transposable element TE35B carries two copies of the white (w) gene at 35B1.2 on the second chromosome. These w genes are suppressed in zeste-1 (z1) mutant background in a synapsis-dependent manner. Single-copy derivatives of the original TE35B stock give red eyes when heterozygous, but zeste eyes when homozygous. TE35B derivatives carrying single, double or triple copies of w were crossed to generate flies carrying from two to five ectopic w genes. Within this range, z1-mediated suppression is insensitive to copynumber and does not distinguish between w genes that are in cis or in trans. Suppression does not require the juxtaposition of even numbers of w genes, but is extremely sensitive to chromosomal topology. When arranged in a tight cluster, in triple-copy TE derivatives, w genes are nonsuppressible. Breakpoints falling within TE35B and separating two functional w genes act as partial suppressors of z1. Similarly, breakpoints immediately proximal or distal to both w genes give partial suppression. This transvection-dependent downregulation of w genes may result from mis-activation of the X-chromosome dosage compensation mechanism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.