ArticleThe British journal of ophthalmology1997
Antioxidant enzymes in the human iris: an immunogold study.
Article in The British journal of ophthalmology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.Molecular vision · 2011Article
- ATM localization and gene expression in the adult mouse eye.Molecular vision · 2009Article
- Immunohistochemical study of glutathione reductase in rat ocular tissues at different developmental stages.The Histochemical journal · 2001Article
- "Oxidative protector" enzymes in the macular retinal pigment epithelium of aging eyes and eyes with age-related macular degeneration.Transactions of the American Ophthalmological Society · 1998Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
aimsTo determine the nature and extent of the antioxidant enzyme system in the human iris.
methodsThe fine structural distribution of five antioxidant enzymes (acidic, neutral, and basic glutathione S-transferase (GST), Cu/Zn superoxide dismutase (Cu/Zn SOD), and glutathione peroxidase) was determined by immunogold labelling of ultrathin sections of tissue from six eyes appropriately fixed for immunocytochemistry and embedded in LR white resin.
resultsBoth Cu/Zn SOD and acidic GST were localised to all constituent cells of the iris. Glutathione peroxidase and basic GST were localised to erythrocytes alone, and labelling for neutral GST was absent.
conclusionsDense labelling for acidic GST could be linked with the previously documented presence of large quantities of polyunsaturated fatty acids in the iris and/or the presence of xenobiotic substances in the aqueous humour.
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