Evidence map›Paper›PMID 9214388›Full record

ArticleThe Journal of cell biology1997

Differential glycosylation of tractin and LeechCAM, two novel Ig superfamily members, regulates neurite extension and fascicle formation.

Y Huang, J Jellies, K M Johansen, J Johansen

Abstract read
In one paragraph

Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Effects of nerve injury and segmental regeneration on the cellular correlates of neural morphallaxis.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2008
    Article
  5. Article
  6. Article
  7. A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Y HuangDepartment of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA.
J Jellies
K M Johansen
J Johansen

Funding

MOLECULAR/FUNCTIONAL ANALYSIS OF AXON FASCICLE PROTEINSR01NS028857 · NINDS · IOWA STATE UNIVERSITY · PI JOHANSEN, JORGEN · 1996 to 2005
$2.0M
MOLECULAR ANALYSIS OF AXON FASCICLE SPECIFIC GLYCOPROTEIR29NS028857 · NINDS · IOWA STATE UNIVERSITY · PI JOHANSEN, JORGEN · 1990 to 1994
–
NINDS NIH HHS NS 28857NINDS NIH HHS R01 NS028857
6 · The paper itself

Abstract

By immunoaffinity purification with the mAb Lan3-2, we have identified two novel Ig superfamily members, Tractin and LeechCAM. LeechCAM is an NCAM/FasII/ApCAM homologue, whereas Tractin is a cleaved protein with several unique features that include a PG/YG repeat domain that may be part of or interact with the extracellular matrix. Tractin and LeechCAM are widely expressed neural proteins that are differentially glycosylated in sets and subsets of peripheral sensory neurons that form specific fascicles in the central nervous system. In vivo antibody perturbation of the Lan3-2 glycoepitope demonstrates that it can selectively regulate extension of neurites and filopodia. Thus, these experiments provide evidence that differential glycosylation can confer functional diversity and specificity to widely expressed neural proteins.

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalCell Adhesion Molecules, NeuronalChromatography, AffinityCloning, MolecularFluorescent Antibody Technique, IndirectGlycosylationLeechesMolecular Sequence DataNerve FibersNeuritesNeurons, AfferentSequence Homology, Amino AcidAntibodies, MonoclonalCAM protein, Hirudo medicinalisCell Adhesion Molecules, Neuronaltractin protein, Hirudo medicinalis

Identifiers

PMID9214388
PMCPMC2139938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.