ArticleThe Plant cell1997
Plant viral synergism: the potyviral genome encodes a broad-range pathogenicity enhancer that transactivates replication of heterologous viruses.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
What it found
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Who cites it
137 citing papers in PubMed, 589 citations in OpenAlex.
- High-Throughput Sequencing Reveals Previously Undetected Viruses and Mixed Infections in Pepper (Viruses · 2026Article
- Nucleotide sequence analysis reveals the presence of PVY-Tam isolates affecting tamarillo in Colombia.Virology journal · 2026Article
- Transcriptomic Profiling of Host Responses Underlying Synergistic Interaction Between the Phloem-Limited Brassica Yellows Virus and Pea Enation Mosaic Virus 2 inPlants (Basel, Switzerland) · 2026Article
- Begomoviral pre-coat protein boosts potato virus X in mixed infection through interfering with antiviral RNAi response.Virology journal · 2025Article
- Potyvirus HcPro Suppressor of RNA Silencing Induces PVY Superinfection Exclusion in a Strain-Specific Manner.International journal of molecular sciences · 2025Article
- The Temporal Order of Mixed Viral Infections Matters: Common Events That Are Neglected in Plant Viral Diseases.Viruses · 2024Review
- Production of Plant Virus-Derived Hybrid Nanoparticles Decorated with Different Nanobodies.ACS nano · 2024Article
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- New persistent plant RNA virus carries mutations to weaken viral suppression of antiviral RNA interference.Molecular plant pathology · 2024Article
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- Plant virus-derived nanoparticles decorated with genetically encoded SARS-CoV-2 nanobodies display enhanced neutralizing activity.Plant biotechnology journal · 2024Article
- Current knowledge and breeding strategies for management of aphid-transmitted viruses of pepper (Frontiers in plant science · 2024Review
- Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense.International journal of molecular sciences · 2023Review
- Visual tracking of viral infection dynamics reveals the synergistic interactions between cucumber mosaic virus and broad bean wilt virus 2.Scientific reports · 2023Article
- A Zinc Finger Motif in the P1 N Terminus, Highly Conserved in a Subset of Potyviruses, Is Associated with the Host Range and Fitness of Telosma Mosaic Virus.Journal of virology · 2023Article
- Co-infection of TYLCV and ToCV increases cathepsin B and promotes ToCV transmission byFrontiers in microbiology · 2023Article
- The Virome of 'Lamon Bean': Application of MinION Sequencing to Investigate the Virus Population Associated with Symptomatic Beans in the Lamon Area, Italy.Plants (Basel, Switzerland) · 2022Article
- Coordinated Action of RTBV and RTSV Proteins Suppress Host RNA Silencing Machinery.Microorganisms · 2022Article
- Genome Editing for Sustainable Agriculture in Africa.Frontiers in genome editing · 2022Review
- Interaction between βC1 of satellite and coat protein of Chili leaf curl virus plays a crucial role in suppression of host RNA silencing.Applied microbiology and biotechnology · 2021Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synergistic viral diseases of higher plants are caused by the interaction of two independent viruses in the same host and are characterized by dramatic increases in symptoms and in accumulation of one of the coinfecting viruses. In potato virus X (PVX)/potyviral synergism, increased pathogenicity and accumulation of PVX are mediated by the expression of potyviral 5' proximal sequences encoding P1, the helper component proteinase (HC-Pro), and a fraction of P3. Here, we report that the same potyviral sequence (termed P1/HC-Pro) enhances the pathogenicity and accumulation of two other heterologous viruses: cucumber mosaic virus and tobacco mosaic virus. In the case of PVX-potyviral synergism, we show that the expression of the HC-Pro gene product, but not the RNA sequence itself, is sufficient to induce the increase in PVX pathogenicity and that both P1 and P3 coding sequences are dispensable for this aspect of the synergistic interaction. In protoplasts, expression of the potyviral P1/HC-Pro region prolongs the accumulation of PVX (-) strand RNA and transactivates expression of a reporter gene from a PVX subgenomic promoter. Unlike the synergistic enhancement of PVX pathogenicity, which requires only expression of HC-Pro, the enhancement of PVX (-) strand RNA accumulation in protoplasts is significantly greater when the entire P1/HC-Pro sequence is expressed. These results indicate that the potyviral P1/HC-Pro region affects a step in disease development that is common to a broad range of virus infections and suggest a mechanism involving transactivation of viral replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.