ArticleChromosoma1997
U14 small nucleolar RNA makes multiple contacts with the pre-ribosomal RNA.
Article in Chromosoma, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- The Efg1-Bud22 dimer associates with the U14 snoRNP contacting the 5' rRNA domain of an early 90S pre-ribosomal particle.Nucleic acids research · 2024Article
- RNA folding and functions of RNA helicases in ribosome biogenesis.RNA biology · 2022Review
- snR30/U17 Small Nucleolar Ribonucleoprotein: A Critical Player during Ribosome Biogenesis.Cells · 2020Review
- Ribosome biogenesis in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs.Nucleic acids research · 2012Article
- Strong dependence between functional domains in a dual-function snoRNA infers coupling of rRNA processing and modification events.Nucleic acids research · 2010Article
- Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis.Molecular cell · 2009Article
- U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis.BMC genomics · 2009Article
- The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.Journal of molecular biology · 2009Article
- Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase.EMBO reports · 2008Article
- Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins.Biochemistry · 2008Article
- Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification.Molecular and cellular biology · 2004Article
- Association of yeast RNA polymerase I with a nucleolar substructure active in rRNA synthesis and processing.The Journal of cell biology · 2000Article
- Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1.The EMBO journal · 1998Article
- Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast.The Journal of biological chemistry · 1998Article
- Conserved boxes C and D are essential nucleolar localization elements of U14 and U8 snoRNAs.The EMBO journal · 1998Article
- The U14 snoRNA is required for 2'-O-methylation of the pre-18S rRNA in Xenopus oocytes.RNA (New York, N.Y.) · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small nucleolar RNA (snoRNA) U14 has two regions of extended primary sequence complementarity to the 18S rRNA. The 3' region (domain B) shows the consensus structure for the methylation guide class of snoRNAs, whereas base-pairing between the 5' region (domain A) and the 18S rRNA sequence is required for the formation of functional ribosomes. Between domains A and B lies another essential region (domain Y). Here we report that yeast U14 can be cross-linked in vivo to the pre-rRNA; cross-linking is detected exclusively with the 35S primary transcript. Many nucleotides in U14 that lie outside of domains A and B are cross-linked to the pre-rRNA; in particular the essential domain Y region is cross-linked at several sites. U14 is, therefore, in far more extensive contact with the pre-rRNA than predicted from simple base-pairing models. Moreover, U14 can be cross-linked to other small RNA species. The functional interactions made by U14 during ribosome synthesis are likely to be very complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.