ArticlePharmaceutical research1997
Aerosol electrostatics. I: Properties of fine powders before and after aerosolization by dry powder inhalers.
Article in Pharmaceutical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Charged Particle Dynamics in Dry Powder Inhalers.Molecular pharmaceutics · 2025Article
- Scale-Up and Postapproval Changes in Orally Inhaled Drug Products: Scientific and Regulatory Considerations.Journal of aerosol medicine and pulmonary drug delivery · 2025Review
- Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels.Scientific reports · 2023Article
- Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy.International journal of pharmaceutics · 2018Article
- Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols.Pharmaceutical research · 2017Article
- Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger.Pharmaceutical research · 2015Article
- Aerodynamic and electrostatic properties of model dry powder aerosols: a comprehensive study of formulation factors.AAPS PharmSciTech · 2014Article
- Effect of crystallinity on electrostatic charging in dry powder inhaler formulations.Pharmaceutical research · 2014Article
- The influence of actuator materials and nozzle designs on electrostatic charge of pressurised metered dose inhaler (pMDI) formulations.Pharmaceutical research · 2014Article
- Development and comparison of new high-efficiency dry powder inhalers for carrier-free formulations.Journal of pharmaceutical sciences · 2014Article
- Electrostatic charge effects on pharmaceutical aerosol deposition in human nasal-laryngeal airways.Pharmaceutics · 2014Article
- New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis.International journal of nanomedicine · 2012Article
- The contribution of different formulation components on the aerosol charge in carrier-based dry powder inhaler systems.Pharmaceutical research · 2010Article
- Introduction of the electrical next generation impactor (eNGI) and investigation of its capabilities for the study of pressurized metered dose inhalers.Pharmaceutical research · 2009Article
- Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers.Pharmaceutical research · 2008Article
- Design of a device for simultaneous particle size and electrostatic charge measurement of inhalation drugs.Pharmaceutical research · 2008Article
- Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols.Pharmaceutical research · 2008Article
- Minimizing variability of cascade impaction measurements in inhalers and nebulizers.AAPS PharmSciTech · 2008Review
- Direct observation of single particle electrostatic charging by atomic force microscopy.Pharmaceutical research · 2007Article
- Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems.Pharmaceutical research · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the dependence of fine particle dose charge (FPD charge) generated from powder inhalers on physico-chemical properties of the inhalation powder, inhaler type, deaggregation mechanism, dose number and/or retained powder.
methodsElectrostatic charges were determined on micronized powders and aerosolized fine particle doses withdrawn from two, high efficiency, multidose powder inhalers, Turbohaler and prototype Dryhaler. The behavior of terbutaline sulfate, budesonide, albuterol (sulfate and base), beclomethasone dipropionate and lactose was assessed before and after aerosolization.
resultsBoth inhalers conferred triboelectric FPD charges during aerosolization in the range -400 pC through +200 pC. Specific charges (charge/unit mass) on the fine particle doses of budesonide from Dryhaler were significantly less than those from Turbohaler (p < 0.01). Electrostatic charges on the potentially respirable cloud of terbutaline sulfate generated by Bricanyl Turbohaler were positive and/or negative and unpredictable. With Pulmicort Turbohaler, FPD charges on budesonide were always positive. Dryhaler was used to determine the chemical dependence of fine particle triboelectrification during the aerosolization of pure materials. A triboelectric series was constructed from the Dryhaler results ranking the powders from positive to negative as budesonide > lactose > albuterol sulfate > terbutaline sulfate > or = albuterol > or = beclomethasone dipropionate.
conclusionsWhile there was no evidence of FPD charge dependence upon dose number with either inhaler, FPD charges were dependent upon the powder under investigation, as well as the construction and deaggregation mechanism of the inhaler. The specific charge on the fine particle dose of budesonide from Turbohaler corresponded to approximately 200 electronic charges per particle, a value which is known to affect both total and regional aerosol deposition in the human lung. Electrostatic charge effects may be important determinants of aerosol behavior and should not be neglected.
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