ArticleJournal of bacteriology1997
Temperate Myxococcus xanthus phage Mx8 encodes a DNA adenine methylase, Mox.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Diverse and unique viruses discovered in the surface water of the East China Sea.BMC genomics · 2020Article
- Bacteriophages ofViruses · 2018Review
- Nucleic Acid Modifications in Regulation of Gene Expression.Cell chemical biology · 2016Review
- Bacteriophage orphan DNA methyltransferases: insights from their bacterial origin, function, and occurrence.Applied and environmental microbiology · 2013Review
- Identification of the cglC, cglD, cglE, and cglF genes and their role in cell contact-dependent gliding motility in Myxococcus xanthus.Journal of bacteriology · 2012Article
- Molecular cloning and characterization of the DNA adenine methyltransferase gene in Feldmannia sp. virus.Virus genes · 2007Article
- Genome and proteome characterization of the psychrophilic Flavobacterium bacteriophage 11b.Extremophiles : life under extreme conditions · 2007Article
- N6-methyladenine: the other methylated base of DNA.BioEssays : news and reviews in molecular, cellular and developmental biology · 2006Review
- Transposon insertions of magellan-4 that impair social gliding motility in Myxococcus xanthus.Genetics · 2006Article
- Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex.Journal of bacteriology · 2006Article
- Genomic and genetic analysis of Bordetella bacteriophages encoding reverse transcriptase-mediated tropism-switching cassettes.Journal of bacteriology · 2004Article
- Site-specific recombination of temperate Myxococcus xanthus phage Mx8: regulation of integrase activity by reversible, covalent modification.Journal of bacteriology · 1999Article
- Site-specific recombination of temperate Myxococcus xanthus phage Mx8: genetic elements required for integration.Journal of bacteriology · 1999Article
- Mutations that confer resistance to 2-deoxyglucose reduce the specific activity of hexokinase from Myxococcus xanthus.Journal of bacteriology · 1999Article
- A chaperone in the HSP70 family controls production of extracellular fibrils in Myxococcus xanthus.Journal of bacteriology · 1998Article
- Genetic determinants of immunity and integration of temperate Myxococcus xanthus phage Mx8.Journal of bacteriology · 1998Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperate bacteriophage Mx8 of Myxococcus xanthus encapsidates terminally repetitious DNA, packaged as circular permutations of its 49-kbp genome. During both lytic and lysogenic development, Mx8 expresses a nonessential DNA methylase, Mox, which modifies adenine residues in occurrences of XhoI and PstI recognition sites, CTCGAG and CTGCAG, respectively, on both phage DNA and the host chromosome. The mox gene is necessary for methylase activity in vivo, because an amber mutation in the mox gene abolishes activity. The mox gene is the only phage gene required for methylase activity in vivo, because ectopic expression of mox as part of the M. xanthus mglBA operon results in partial methylation of the host chromosome. The predicted amino acid sequence of Mox is related most closely to that of the methylase involved in the cell cycle control of Caulobacter crescentus. We speculate that Mox acts to protect Mx8 phage DNA against restriction upon infection of a subset of natural M. xanthus hosts. One natural isolate of M. xanthus, the lysogenic source of related phage Mx81, produces a restriction endonuclease with the cleavage specificity of endonuclease BstBI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.