ArticleProceedings of the National Academy of Sciences of the United States of America1997
Reduced fertility in mice deficient for the POU protein sperm-1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis.Nucleic acids research · 2018Article
- Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice.Biology of reproduction · 2015Article
- Article
- Oct transcription factors in development and stem cells: insights and mechanisms.Development (Cambridge, England) · 2013Review
- CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending.PLoS genetics · 2013Article
- Misexpression of testicular microRNA in sterile Xenopus hybrids points to tetrapod-specific microRNAs associated with male fertility.Journal of molecular evolution · 2011Article
- Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.The Journal of clinical investigation · 2010Article
- The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.Fertility and sterility · 2010Article
- CIB1 is essential for mouse spermatogenesis.Molecular and cellular biology · 2006Article
- Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.Development (Cambridge, England) · 2005Article
- Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis.Molecular and cellular biology · 2004Article
- Reduced fertility in male mice deficient in the zinc metallopeptidase NL1.Molecular and cellular biology · 2004Article
- A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Regulation of IkappaBbeta expression in testis.Molecular biology of the cell · 2002Article
- Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene.Molecular and cellular biology · 2002Article
- Transcriptome research on spermatogenic molecular drive in mammals.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.