ArticleProceedings of the National Academy of Sciences of the United States of America1997
Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 94 citations in OpenAlex.
- Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.Acta neuropathologica communications · 2023Article
- RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.Breast cancer : basic and clinical research · 2014Article
- The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament.DNA repair · 2013Article
- Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without Helicobacter pylori infection.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Choosing the right path: does DNA-PK help make the decision?Mutation research · 2011Review
- Plant DNA recombinases: a long way to go.Journal of nucleic acids · 2010Article
- Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL.The Journal of biological chemistry · 2009Article
- Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells.Plant molecular biology · 2005Article
- Ultraviolet light selection assay to optimize oligonucleotide correction of mutations in endogenous xeroderma pigmentosum genes.Gene therapy · 2004Article
- Preferential binding to branched DNA strands and strand-annealing activity of the human Rad51B, Rad51C, Rad51D and Xrcc2 protein complex.Nucleic acids research · 2004Article
- Domain mapping of the Rad51 paralog protein complexes.Nucleic acids research · 2004Article
- Region and amino acid residues required for Rad51C binding in the human Xrcc3 protein.Nucleic acids research · 2003Article
- Etiology and pathogenesis of uterine leiomyomas: a review.Environmental health perspectives · 2003Review
- Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.Nucleic acids research · 2002Article
- Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.Nucleic acids research · 2002Article
- Identification and purification of two distinct complexes containing the five RAD51 paralogs.Genes & development · 2001Article
- Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells.The EMBO journal · 2001Article
- Complex formation by the human RAD51C and XRCC3 recombination repair proteins.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Homologous DNA recombination in vertebrate cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.Oncogene · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A human and a mouse gene have been isolated based on homology to a recombinational repair gene from the corn smut Ustilago maydis. The new human (h) gene, termed hREC2, bears striking resemblance to several others, including hRAD51 and hLIM15. hREC2 is located on human chromosome 14 at q23-24. The overall amino acid sequence reveals characteristic elements of a RECA-like gene yet harbors an src-like phosphorylation site curiously absent from hRAD51 and hLIM15. Unlike these two relatives, hREC2 is expressed in a wide range of tissues including lung, liver, placenta, pancreas, leukocytes, colon, small intestine, brain, and heart, as well as thymus, prostate, spleen, and uterus. Of greatest interest is that hREC2 is undetectable by reverse transcription-coupled PCR in tissue culture unless the cells are treated by ionizing radiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.