ArticleProceedings of the National Academy of Sciences of the United States of America1997
Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 191 citations in OpenAlex.
- Risk Factors for Pancreatic Cancer: Emerging Role of Viral Hepatitis.Journal of personalized medicine · 2022Review
- Serous Membrane Detachment with Ultrasonic Homogenizer Improves Engraftment of Fetal Liver to Liver Surface in a Rat Model of Cirrhosis.International journal of molecular sciences · 2021Article
- Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s).American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Impact of prevailing thiamin levels on thiamin pyrophosphate uptake in pancreatic acinar cells: do the shuttle!American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- In Vitro and In Vivo Hepatic Differentiation of Adult Somatic Stem Cells and Extraembryonic Stem Cells for Treating End Stage Liver Diseases.Stem cells international · 2015Review
- Article
- The use of cellular technologies in treatment of liver pathologies.Acta naturae · 2012Article
- Ontogenesis of hepatic and pancreatic stem cells.Stem cell reviews and reports · 2012Review
- A rare case of metastatic pancreatic hepatoid carcinoma treated with sorafenib.Journal of gastrointestinal cancer · 2012Article
- Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.Liver international : official journal of the International Association for the Study of the Liver · 2012Article
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
- Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells.Journal of transplantation · 2011Article
- Progenitor cells for regenerative medicine and consequences of ART and cloning-associated epimutations.Molecular biotechnology · 2010Review
- Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver.Cell stress & chaperones · 2010Article
- Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Stem cells and liver regeneration.Gastroenterology · 2009Review
- Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model.Oncology research · 2009Article
- Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice.Stem cells (Dayton, Ohio) · 2008Article
- Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo.Hepatology international · 2008Article
- Stem cells, cell transplantation and liver repopulation.Biochimica et biophysica acta · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The ability to identify, isolate, and transplant progenitor cells from solid tissues would greatly facilitate the treatment of diseases currently requiring whole organ transplantation. In this study, cell fractions enriched in candidate epithelial progenitor cells from the rat pancreas were isolated and transplanted into the liver of an inbred strain of Fischer rats. Using a dipeptidyl dipeptidase IV genetic marker system to follow the fate of transplanted cells in conjunction with albumin gene expression, we provide conclusive evidence that, after transplantation to the liver, epithelial progenitor cells from the pancreas differentiate into hepatocytes, express liver-specific proteins, and become fully integrated into the liver parenchymal structure. These studies demonstrate the presence of multipotent progenitor cells in the adult pancreas and establish a role for the liver microenvironment in the terminal differentiation of epithelial cells of foregut origin. They further suggest that such progenitor cells might be useful in studies of organ repopulation following acute or chronic liver injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.