ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Differential activation and desensitization of sensory neurons by resiniferatoxin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
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- TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.Nature communications · 2017Article
- Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.Hearing research · 2005Article
- Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice.British journal of pharmacology · 2004Article
- Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin.British journal of pharmacology · 2003Article
- Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores.British journal of pharmacology · 2003Article
- Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide.British journal of pharmacology · 2002Article
- Effect of vanilloid drugs on gastrointestinal transit in mice.British journal of pharmacology · 2001Article
- Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.British journal of pharmacology · 2000Article
- Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Transient receptor potential channels in pain and inflammation: therapeutic opportunities.Pain practice : the official journal of World Institute of PainReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, with use of rat dorsal root ganglion (DRG) neurons we have been able to dissociate the binding affinities of vanilloids from their potencies to induce 45Ca uptake, which suggests the existence of distinct classes of the vanilloid receptor (). In the present study, we have demonstrated that the ultrapotent capsaicin analog resiniferatoxin (RTX) desensitized rat DRG neurons to the subsequent induction of 45Ca uptake by capsaicin and RTX with affinity and cooperativity similar to that found for [3H]RTX binding, contrasting with a approximately 10-fold weaker potency and lack of cooperativity to induce 45Ca uptake. Likewise, the competitive antagonist capsazepine inhibited RTX-induced desensitization with potency similar to that for inhibition of specific [3H]RTX binding, whereas the potency of capsazepine was approximately 10-fold higher for inhibiting RTX-induced 45Ca uptake. Finally, the noncompetitive antagonist ruthenium red inhibited both the RTX-induced desensitization and 45Ca uptake but showed approximately 60-fold selectivity for inhibiting RTX-induced desensitization. The RTX-induced desensitization was not associated with loss of specific [3H]RTX binding, suggesting lack of gross cell toxicity. In contrast to RTX, capsaicin caused desensitization with a potency corresponding to that for 45Ca uptake and did so in a noncooperative manner. Unlike the RTX-induced desensitization, the desensitization by capsaicin was blocked by ruthenium red only at doses that blocked 45Ca uptake and depended on external calcium. Our findings provide further support for the existence of vanilloid receptor subtypes on DRG neurons with distinct pharmacology and distinct patterns of desensitization.
Indexed as
Identifiers
9204943PMC6793835W2122773953What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.