ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
GABAergic neurons in barrel cortex show strong, whisker-dependent metabolic activation during normal behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- Conserved Kir channel mechanisms governing intrinsic excitability in human and rodent parvalbumin neurons.Communications biology · 2026Article
- Dopaminergic Innervation of the Nidopallium Caudolaterale in the Japanese Quail.The Journal of comparative neurology · 2026Article
- Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds.PLoS biology · 2025Article
- Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels.bioRxiv : the preprint server for biology · 2025Article
- Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability.Science advances · 2021Article
- More than just summed neuronal activity: how multiple cell types shape the BOLD response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer's Disease.Frontiers in behavioral neuroscience · 2021Review
- Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?Brain sciences · 2019Review
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia.Molecular psychiatry · 2019Article
- A Quantitative Study on the Distribution of Mitochondria in the Neuropil of the Juvenile Rat Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- The restless brain: how intrinsic activity organizes brain function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Highly energized inhibitory interneurons are a central element for information processing in cortical networks.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Article
- R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.British journal of pharmacology · 2010Article
- Rapid, learning-induced inhibitory synaptogenesis in murine barrel field.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A paradigm shift in functional brain imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Electrophysiological data from the rodent whisker/barrel cortex indicate that GABAergic, presumed inhibitory, neurons respond more vigorously to stimulation than glutamatergic, presumed excitatory, cells. However, these data represent very small neuronal samples in restrained, anesthetized, or narcotized animals or in cortical slices. Histochemical data from primate visual cortex, stained for the mitochondrial enzyme cytochrome oxidase (CO) and for GABA, show that GABAergic neurons are more highly reactive for CO than glutamatergic cells, indicating that inhibitory neurons are chronically more active than excitatory neurons but leaving doubt about the short-term stimulus dependence of this activation. Taken together, these results suggest that highly active inhibitory neurons powerfully influence relatively inactive excitatory cells but do not demonstrate directly the relative activities of excitatory and inhibitory neurons in the cortex during normal behavior. We used a novel double-labeling technique to approach the issue of excitatory and inhibitory neuronal activation during behavior. Our technique combines high-resolution 2-deoxyglucose (2DG), immunohistochemical staining for neurotransmitter-specific antibodies, and automated image analysis to collect the data. We find that putative inhibitory neurons in barrel cortex of behaving animals are, on average, much more heavily 2DG-labeled than presumed excitatory cells, a pattern not seen in animals anesthetized at the time of 2DG injection. This metabolic activation is dependent specifically on sensory inputs from the whiskers, because acute trimming of most whiskers greatly reduces 2DG labeling in both cell classes in columns corresponding to trimmed whiskers. Our results provide confirmation of the active GABAergic cell hypothesis suggested by CO and single-unit data. We conclude that strong activation of inhibitory cortical neurons must confer selective advantages that compensate for its inherent energy inefficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.