ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Nerve growth factor stimulates the accumulation of beta1 integrin at the tips of filopodia in the growth cones of sympathetic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 90 citations in OpenAlex.
- Axonal pathfinding during the development of the nervous system.Annals of the Child Neurology Society · 2023Review
- Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells.Molecular biology of the cell · 2015Article
- The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.Developmental neurobiology · 2015Article
- The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope.Cell reports · 2013Article
- The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions.Cancer discovery · 2012Article
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth.BMC biology · 2011Article
- Microfluidic generation of haptotactic gradients through 3D collagen gels for enhanced neurite growth.Journal of neurotrauma · 2011Article
- Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.Developmental neurobiology · 2010Article
- Intracellular control of developmental and regenerative axon growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Semaphorins command cells to move.Nature reviews. Molecular cell biology · 2005Review
- Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Integrins regulate responsiveness to slit repellent signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Rapid neuromodulatory actions of integrin ligands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Two-tiered inhibition of axon regeneration at the dorsal root entry zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Recycling of the cell adhesion molecule L1 in axonal growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Extracellular matrix signaling: integration of form and function in normal and malignant cells.Current opinion in cell biology · 1998Review
- Genetic analysis on the role of integrin during axon guidance in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Addition of nerve growth factor (NGF) to sympathetic neurons that have been starved of it causes a rapid induction of growth cone motility and the resumption of neurite growth. Using immunofluorescence staining, we show that within 10 min, NGF stimulated the accumulation of dense aggregates of beta1 integrin [a receptor for extracellular matrix (ECM) proteins] at most of the tips of either newly extended or preexisting filopodia. This effect occurred in the absence of ECM proteins and in the presence of 1 mg/ml Arg-Gly-Asp-Ser peptide, which blocks ECM binding to integrin, indicating that occupation of the integrin receptor is not necessary for tip localization. In fact, addition of either laminin or fibronectin caused a rapid withdrawal of beta1 integrin aggregates from filopodial tips at a rate comparable to that of the rearward flow of actin filaments in the periphery of the growth cone. Surface labeling of the extracellular domain of beta1 integrin while aggregated at the tips of filopodia or withdrawing in response to ECM proteins showed that the receptor is positioned within the membrane. The drug butanedione monoxime, an inhibitor of myosins, blocked the accumulation of beta1 integrin at the tips of filopodia without inhibiting the formation of filo-podia, suggesting the involvement of a myosin motor in beta1 integrin transport. These results provide the first evidence of NGF-mediated accumulation of ECM receptors to sensory elements of the growth cone and suggest one mechanism whereby soluble and substrate-bound cues coordinate to produce directed neurite growth.
Indexed as
Identifiers
9204928PMC6793820W2142479550What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.