Evidence map›Paper›PMID 9204918›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997

cAMP-dependent enhancement of dihydropyridine-sensitive calcium channel availability in hippocampal neurons.

E T Kavalali, K S Hwang, M R Plummer

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Estimation of cAMP binding in hippocampus CA1 field by a fluorescent probe.Frontiers in cell and developmental biology · 2023
    Article
  3. Review
  4. Green fluorescent cAMP indicator of high speed and specificity suitable for neuronal live-cell imaging.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Review
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  8. Article
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  14. Review
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  19. Article
  20. Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E T KavalaliDepartment of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855-1059, USA.
K S Hwang
M R Plummer
Rutgers, The State University of New Jersey · US

Funding

CALCIUM CURRENT POTENTIATION IN HIPPOCAMPAL NEURONSR01NS034061 · NINDS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI PLUMMER, MARK R. · 1995 to 1997
–
NINDS NIH HHS NS 34061
6 · The paper itself

Abstract

Dihydropyridine-sensitive calcium channels can be strongly modulated by cAMP-dependent phosphorylation. This modulation takes the form of increased channel availability in cardiac myocytes (for review, see McDonald et al., 1994) and has been suggested to be essential for voltage-dependent facilitation in adrenal chromaffin cells (Artalejo et al., 1992) and skeletal muscle (Sculptoreanu et al., 1993b). To determine the role of cAMP-dependent phosphorylation on dihydropyridine-sensitive calcium channels in hippocampal neurons, we have used both single-channel and whole-cell recording techniques and have examined the effects of the membrane-permeable cAMP analog 8-(4-chlorophenylthio) (CPT)-cAMP and the protein kinase inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) and N-[2-(p-bromocinnamyl-amino)ethyl]-5-isoquinolinesulfonamide (H-89). Hippocampal neurons contain two kinds of dihydropyridine-sensitive calcium channel activity: Ls and Lp (Kavalali and Plummer, 1994). The Ls channel closely resembles the cardiac L-type channel, whereas the Lp channel shows a novel low-voltage form of voltage-dependent potentiation (). 8-CPT-cAMP increased the availability of both the Ls and Lp channels and caused a parallel increase in Lp channel reopenings at the repolarization potential that result from voltage-dependent potentiation. This effect was completely blocked by the broad spectrum kinase inhibitor H-7 and by the protein kinase A-specific inhibitor H-89. The two inhibitors, however, did not disrupt baseline potentiation of the Lp channel, suggesting that cAMP-dependent protein kinase activity can enhance Ls and Lp channel activity but is not required for voltage-dependent potentiation in hippocampal neurons.

Indexed as

AnimalsCalcium Channel BlockersCalcium ChannelsCyclic AMPDihydropyridinesHippocampusRatsRats, Sprague-Dawley1,4-dihydropyridineCalcium Channel BlockersCalcium ChannelsCyclic AMPDihydropyridines

Identifiers

PMID9204918
PMCPMC6793811
OpenAlexW1766685154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.