ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Nerve growth factor accelerates seizure development, enhances mossy fiber sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 123 citations in OpenAlex.
- Vitamin D is involved in regulating limbic epileptogenesis.Brain communications · 2026Article
- Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive Therapies─In Vitro and In Vivo Characterization.ACS chemical neuroscience · 2024Article
- Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders.Neural regeneration research · 2022Review
- Identification of epilepsy related pathways using genome-wide DNA methylation measures: A trio-based approach.PloS one · 2019Article
- The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus.Neuroscience · 2015Article
- Involvement of central TRPV1 receptors in pentylenetetrazole and amygdala-induced kindling in male rats.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome.Acta neuropathologica communications · 2014Article
- Enhanced mossy fiber sprouting and synapse formation in organotypic hippocampal cultures following transient domoic acid excitotoxicity.Neurotoxicity research · 2014Article
- Article
- Effect of different mild hypoxia manipulations on kainic acid-induced seizures in the hippocampus of rats.Neurochemical research · 2013Article
- Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy.Journal of molecular neuroscience : MN · 2013Article
- Is epilepsy a preventable disorder? New evidence from animal models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2010Review
- Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat.Cellular and molecular neurobiology · 2010Article
- Separating kindling and LTP: lessons from studies of PKM zeta in developing and adult rats.Neuroscience letters · 2009Article
- Progress in neuroprotective strategies for preventing epilepsy.Progress in neurobiology · 2008Review
- Differential regulation of c-Fos and FosB in the rat brain after amygdala kindling.Cellular and molecular neurobiology · 2006Article
- Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures.Experimental brain research · 2004Article
- A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent seizure activity induced during kindling has been reported to produce a functional synaptic reorganization of the mossy fibers in the hippocampus. To date, it is unclear whether this kindling-induced growth is secondary to decreases in hilar neuron density, which are presumed to reflect hilar neuronal cell loss, or whether it is related specifically to an activation-dependent plasticity. We recently demonstrated that blocking nerve growth factor (NGF) biological activity retards seizure development and inhibits the sprouting of mossy fibers. We now demonstrate that intraventricular administration of NGF itself accelerates the progression of kindling epileptogenesis, increases mossy fiber sprouting in the CA3 region and in the inner molecular layer (IML), but reduces seizure-induced decreases in hilar cell density. These findings provide support for a role of NGF in kindling and kindling-induced mossy fiber sprouting. In addition, the results dissociate this form of epileptogenesis from hilar cell loss or decreases in hilar cell density attributable to increases in hilar area, thereby supporting seizure-induced mossy fiber sprouting as being primarily attributable to the combined effects of neuronal activation and the activation-induced upregulation of growth factors.
Indexed as
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9204913PMC6793837W1553756657What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.