ReviewEmerging infectious diseases
Brucellosis: an overview.
Review in Emerging infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 461 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
461 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,287 citations in OpenAlex.
- Scoping review of brucellosis in Armenia: persistent neglect, significant knowledge gaps, and a necessity for innovative research, surveillance, and control.Frontiers in veterinary science · 2025Pooled it
- Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania.Scientific reports · 2020Trial
- Intersecting threats:International journal for parasitology. Parasites and wildlife · 2026Article
- Beyond Acute Infection: A Conceptual Framework Linking Zoonotic Bacterial Pathogens to Pulmonary Fibrosis and Lung Carcinogenesis.Biomedicines · 2026Review
- Acute Febrile Illness With Triple Co-Infection: A Case Report on the Diagnostic Challenges of Overlapping Febrile Illnesses.Clinical case reports · 2026Article
- Unveiling brucellosis risks in breeding herds: Case study on diagnostic failures and control gaps in South Africa.The Onderstepoort journal of veterinary research · 2026Article
- Brucellosis in the One Health Context: Gaps in Diagnosis, Control, and Global Epidemiology.Journal of epidemiology and global health · 2026Review
- Fetal and neonatal demise in zoonotic diseases: pathology and pathogenesis.Infection and immunity · 2026Review
- Pathogenicity ofTropical medicine and infectious disease · 2026Article
- Article
- Brucellosis vaccine development: immunological mechanisms, animal models, and future directions.Archives of microbiology · 2026Review
- Brucellosis involving the aorta and iliac arteries: a single-center experience.BMC infectious diseases · 2026Observational
- Brucella abortus infection exploits ZDHHC3-mediated STAT3 palmitoylation to regulate host responses and promote persistence.Veterinary research · 2026Article
- Brucellosis in healthcare settings: research advances in nosocomial infection prevention and control.Frontiers in public health · 2026Review
- County-level spatiotemporal patterns, forecasting, and non-fatal burden of human brucellosis in Hulunbuir, China, 2016-2025.Frontiers in public health · 2026Article
- Evaluation of brucellosis eradication strategies in water buffalo in a key dairy production area of southern Italy.Frontiers in microbiology · 2026Article
- Integrated Surveillance for Human and Animal Brucellosis in Kenya: A Predictive Analysis.Tropical medicine and infectious disease · 2025Article
- Pathogenicity and virulence ofVirulence · 2025Review
- A scoping review of the national strategy for brucellosis control in Egypt: logic framework, challenges, and prospects.One health outlook · 2025Review
- Development and evaluation of a novel lateral flow immunoassay for rapid diagnosis of brucellosis across different animal species.Scientific reports · 2025Article
401 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis remains a major zoonosis worldwide. Although many countries have eradicated Brucella abortus from cattle, in some areas Brucella melitensis has emerged as a cause of infection in this species as well as in sheep and goats. Despite vaccination campaigns with the Rev 1 strain, B. melitensis remains the principal cause of human brucellosis. Brucella suis is also emerging as an agent of infection in cattle, thus extending its opportunities to infect humans. The recent isolation of distinctive strains of Brucella from marine mammals has extended its ecologic range. Molecular genetic studies have demonstrated phylogenetic affiliation to Agrobacterium, Phyllobacterium, Ochrobactrum, and Rhizobium. Polymerase chain reaction and gene probe development may provide more effective typing methods. Pathogenicity is related to production of lipopolysaccharides containing a poly N-formyl perosamine O chain, CuZn superoxide dismutase, erythrlose phosphate dehydrogenase, stress-induced proteins related to intracellular survival, and adenine and guanine monophosphate inhibitors of phagocyte functions. Protective immunity is conferred by antibody to lipopolysaccharide and T-cell-mediated macrophage activation triggered by protein antigens. Diagnosis still centers on isolation of the organism and serologic test results, especially enzyme immunoassay, which is replacing other methods. Polymerase chain reaction is also under evaluation. Therapy is based on tetracyclines with or without rifampicin, aminoglycosides, or quinolones. No satisfactory vaccines against human brucellosis are available, although attenuated purE mutants appear promising.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.