ArticleImmunology1997
Two distinct pathways of human macrophage differentiation are mediated by interferon-gamma and interleukin-10.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.Scientific reports · 2016Article
- Xuebijing injection improves the respiratory function in rabbits with oleic acid-induced acute lung injury by inhibiting IL-6 expression and promoting IL-10 expression at the protein and mRNA levels.Experimental and therapeutic medicine · 2014Article
- Cytokine production is altered in monocytes from children with hemolytic uremic syndrome.Journal of clinical immunology · 2012Article
- Non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation.Clinical and experimental immunology · 2005Article
- Article
- CD14+CD16+ monocyte subpopulation in Kawasaki disease.Clinical and experimental immunology · 2000Article
- Macrophages from inflamed but not normal glomeruli are unresponsive to anti-inflammatory cytokines.The American journal of pathology · 2000Article
- Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo.The American journal of pathology · 1999Article
- Elevated major histocompatibility complex class I expression protects T cells from antibody- and macrophage-mediated deletion.Immunology · 1998Article
Corrections and comments
- Erratum issuedOlikowsky, T [corrected to Orlikowsky T]
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Forming cellular conjugates with T cells, macrophages can help their targets to mount an immune response or they can destroy the targeted T cell. The two functions are performed by two distinct macrophage subsets that can be distinguished by cell surface marker phenotypes, B7+ CD16- and B7- CD16+. Interferon-gamma (IFN-gamma) induces the former, interleukin-10 (IL-10) induces the latter phenotype. The two macrophage differentiation pathways are mutually exclusive; each cytokine inhibits the effect of the other cytokine. The second messenger cAMP enhances the macrophage B7 expression and suppresses the macrophage CD16 expression. However, together with IL-10, cAMP blocks the generation of both macrophage phenotypes. In the chimpanzee we noted deviations from this differentiation pattern that are suggestive of an enhanced IL-10 presence in the primate environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.