ArticleJournal of neural transmission (Vienna, Austria : 1996)1997
Learning abilities depend on NMDA-receptor density in hippocampus in adult rats.
Article in Journal of neural transmission (Vienna, Austria : 1996), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Neural vs Neuromorphic Interfaces: Where Are We Standing?Chemical reviews · 2025Review
- Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate.Cells · 2024Review
- Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide.The Australian and New Zealand journal of psychiatry · 2016Article
- The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Effect of ageing on Ca2+ uptake via NMDA receptors into barrel cortex slices of spontaneously hypertensive rats.Metabolic brain disease · 2008Article
- From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain.Journal of neural transmission (Vienna, Austria : 1996) · 2006Review
- Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus.Neurochemical research · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampal NMDA-receptor is predominantly involved to establish long-term potentiation (LTP) which is assumed to underlie fundamental molecular mechanisms of learning and memory. In the present study, NMDA-receptor density was investigated in parietotemporal cerebral cortex and in hippocampus of commonly bred naive adult male Wistar rats which had performed well or poorly in the passive avoidance paradigm. NMDA-receptor binding was determined in saturation experiments using (3H) MK-801 as a ligand and data for KD and Bmax were calculated from Scatchard plots. In general, higher NMDA receptor density was found in the hippocampus as compared to parietotemporal cerebral cortex. This regional difference became particularly obvious in good performers but was abolished in poor performers. In the hippocampus, a significantly higher NMDA-receptor density could be found in rats which had performed well in the passive avoidance task as compared to poor performers. In contrast, no such differences could be found in parietotemporal cerebral cortex. The data may indicate that the reduction in hippocampal NMDA-receptor density is of functional importance, for cognitive abilities in both physiological and pathophysiological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.