ArticleDigestive diseases and sciences1997
Serum n3 polyunsaturated fatty acids are depleted in Crohn's disease.
Article in Digestive diseases and sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease.The Cochrane database of systematic reviews · 2014Pooled it
- Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis.The Cochrane database of systematic reviews · 2007Pooled it
- Markers of Gut Health in Small Animals: Focus on Fatty Acids and Amino Acids as Indicators of Intestinal Functionality and Microbiome Activity.Animals : an open access journal from MDPI · 2025Review
- A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy.Metabolites · 2022Article
- Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2021Article
- Significance of serum palmitoleic acid levels in inflammatory bowel disease.Scientific reports · 2021Article
- Article
- Is there a role for fish oil in inflammatory bowel disease?World journal of clinical cases · 2014Review
- The role of macrophages and dendritic cells in the initiation of inflammation in IBD.Inflammatory bowel diseases · 2014Review
- An overview of lipid abnormalities in patients with inflammatory bowel disease.Annals of gastroenterology · 2011Review
- Soybean and fish oil mixture increases IL-10, protects against DNA damage and decreases colonic inflammation in rats with dextran sulfate sodium (DSS) colitis.Lipids in health and disease · 2010Article
- TGFbeta1 expression in colonic mucosa: modulation by dietary lipids.Genes & nutrition · 2007Article
- The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes.Clinical and experimental immunology · 2005Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine fatty acid patterns in Crohn's disease, we measured various serum fatty acids by gas chromatography in 20 patients with the disease and compared them with those in 18 healthy controls. All the patients had been free from any nutritional supplementation during preceding six months or had no history of intestinal resection. Eight of the patients were affected in the small bowel only, three in the large bowel only, and the remaining nine in both the small and large bowel. Both serum concentrations and percentages of C20:4n6, C20:5n3, C22:0, C22:6n3, total n3 polyunsaturated fatty acids, and total polyunsaturated fatty acids were lower in the patients than in the controls. Both essential fatty acids (C18:2n6, C18:3n3) and C20:3n9 levels were not different between the two groups. Among nine fatty acids that correlated with the Crohn's disease activity index, C20:5n3 and total n3 polyunsaturated fatty acids showed the most significant negative correlations. These findings suggest that essential fatty acid deficiency rarely occurs in Crohn's disease and also that n3 polyunsaturated fatty acids may be relevant to the activity of the disease.
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