ArticleJournal of immunology (Baltimore, Md. : 1950)1997
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation.
Article in Journal of immunology (Baltimore, Md. : 1950), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Autoreactive B cells in SLE, villains or innocent bystanders?Immunological reviews · 2019Review
- Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.Journal of autoimmunity · 2012Article
- Article
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling.Journal of leukocyte biology · 2009Article
- The transmembrane tyrosine of micro-heavy chain is required for BCR destabilization and entry of antigen into clathrin-coated vesicles.International immunology · 2007Article
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
- The riddle of the dual expression of IgM and IgD.Immunology · 2006Review
- Independent trafficking of Ig-alpha/Ig-beta and mu-heavy chain is facilitated by dissociation of the B cell antigen receptor complex.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes.The EMBO journal · 2002Article
- Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells.Journal of immunology (Baltimore, Md. : 1950) · 2002Article
- Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.The Journal of experimental medicine · 1999Article
- Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization.Immunity · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Antigen binding to the B cell receptor (BCR) induces receptor desensitization, a condition characterized by cellular unresponsiveness to subsequent Ag stimulation despite the continued ability to bind Ag. To better understand the molecular mechanism of this unresponsiveness, we have used complementary lymphoma (K46 mu) and Ig transgenic (3-83 mu delta) mouse models to study regulation of BCR signaling. Our findings in the lymphoma model show that an initial Ag encounter renders receptors unresponsive to subsequent Ag challenge, as measured by their inability to mobilize Ca2+ and to mediate phosphorylation of receptor-proximal kinases, including Lyn, Blk, and Syk. Most importantly, the Ig alpha and Ig beta components of desensitized receptors are not phosphorylated, and receptor-associated kinases are not activated upon Ag challenge. The molecular defect does not appear to result from Lyn inactivation, sequestration, or repression, since Lyn from desensitized cell lysates is activated in vitro by synthetic doubly phosphorylated immunoreceptor tyrosine-based activation motif peptides. A similar deficit in Ag-induced receptor phosphorylation was observed in desensitized B cells from 3-83 mu delta transgenic mice. These studies indicate that Ag receptor desensitization reflects an inability to initiate activation of receptor-associated kinases that normally phosphorylate receptor Ig alphabeta subunits, leading to signal propagation.
Indexed as
Identifiers
9200459PMC3931421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.