ArticleAmerican journal of human genetics1997
Fine-scale genetic mapping based on linkage disequilibrium: theory and applications.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Article
- Review
- A fast expectation-maximum algorithm for fine-scale QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- A composite-likelihood approach for identifying polymorphisms that are potentially directly associated with disease.European journal of human genetics : EJHG · 2009Article
- Genomewide association studies: history, rationale, and prospects for psychiatric disorders.The American journal of psychiatry · 2009Review
- Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies.BMC genomics · 2007Article
- Article
- A fine-scale linkage-disequilibrium measure based on length of haplotype sharing.American journal of human genetics · 2006Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping.American journal of human genetics · 2005Article
- Linkage disequilibrium and association studies in higher plants: present status and future prospects.Plant molecular biology · 2005Review
- Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK.Human genetics · 2005Article
- Simultaneous detection of linkage disequilibrium and genetic differentiation of subdivided populations.Genetics · 2004Article
- Article
- A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis.Genetics · 2003Article
- Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies.American journal of human genetics · 2002Article
- Score tests for association between traits and haplotypes when linkage phase is ambiguous.American journal of human genetics · 2002Article
- Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations.Genetics · 2002Article
- Single nucleotide polymorphisms and disease gene mapping.Arthritis research · 2002Review
- Bayesian analysis of haplotypes for linkage disequilibrium mapping.Genome research · 2001Article
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2 authors.
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Abstract
Linkage-disequilibrium mapping (LDM) recently has been hailed as a powerful statistical method for fine-scale mapping of disease genes. After reviewing its historical background and methodological development, we present a general, mathematical, and conceptually coherent framework for LDM that incorporates multilocus and multiallelic markers and mutational processes at the marker and disease loci. With this framework, we address several issues relevant to fine-scale mapping and propose some efficient computational methods for LDM. We implement various LDM methods that incorporate population growth, recurrent mutation, and marker mutations, on the basis of a general framework. We demonstrate these methods by applying them to published data on cystic fibrosis, Huntington disease, Friedreich ataxia, and progressive myoclonus epilepsy. Since the genes responsible for these diseases all have been cloned, we can evaluate the performance of our methods and can compare ours with that of other methods. Using the proposed methods, we successfully and accurately predicted the locations of genes responsible for these diseases, on the basis of published data only.
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