ArticleAmerican journal of human genetics1997
Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Trial
- Age effect on the shared etiology of glycemic traits and serum lipids: evidence from a Chinese twin study.Journal of endocrinological investigation · 2024Article
- NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Article
- Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study.Genetic epidemiology · 2021Article
- Progressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data.Genes & genomics · 2020Article
- Heritability and Genome-Wide Association Study of Plasma Cholesterol in Chinese Adult Twins.Frontiers in endocrinology · 2018Article
- Genetic and Environmental Regulation on Longitudinal Change of Metabolic Phenotypes in Danish and Chinese Adult Twins.PloS one · 2016Article
- Genome-wide linkage and positional association analyses identify associations of novel AFF3 and NTM genes with triglycerides: the GenSalt study.Journal of genetics and genomics = Yi chuan xue bao · 2015Article
- A genome-wide association analysis for porcine serum lipid traits reveals the existence of age-specific genetic determinants.BMC genomics · 2014Article
- Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI.Obesity (Silver Spring, Md.) · 2014Article
- Longitudinal association analysis of quantitative traits.Genetic epidemiology · 2012Article
- Evidence for age as a modifier of genetic associations for lipid levels.Annals of human genetics · 2011Article
- Adult hypertension is associated with blood pressure variability in childhood in blacks and whites: the bogalusa heart study.American journal of hypertension · 2011Article
- Genome-wide association study of biochemical traits in Korcula Island, Croatia.Croatian medical journal · 2009Article
- Heritability of serum apolipoprotein concentrations in middle-aged Japanese twins.Journal of epidemiology · 2009Article
- Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.Nature genetics · 2009Article
- Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities.Diabetologia · 2007Article
- A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Numerous studies have demonstrated genetic influences on levels of coronary heart disease (CHD) risk factors, but there also may be genetic effects on the intraindividual variation in these risk factors over time. Changes in risk factors are likely to reflect genetic-environmental interactions and may have important implications for understanding CHD risk. The present study examines the heritability of changes in CHD risk factors, using data from the two examinations by the Kaiser Permanente Women Twins Study, performed a decade apart. The sample consisted of 348 pairs of women twins who participated in both examinations, including 203 MZ pairs and 145 DZ pairs. Average ages at the two examinations were 41 and 51 years, respectively. By means of three different statistical analytic approaches, moderate heritability estimates were demonstrated for changes in LDL cholesterol (h2 = .25-.36) and in HDL cholesterol (h2 = .23-.58), some of which were statistically significant. Although small to moderate heritability estimates were found for systolic blood pressure (.18-.37; P < .05 for some estimates), no genetic influence on changes in diastolic blood pressure was detected. Based on longitudinal twin data in women, this study demonstrates a genetic influence on changes in both lipoprotein risk factors and systolic blood pressure over a decade. In addition to environmental factors, which clearly are operating, the effect of various "variability genes" may be acting independently of the genetic influences on the absolute levels of these risk factors. Both mapping the gene(s) underlying intraindividual variations in these CHD risk factors and understanding their function(s) could lead to targeted intervention strategies to reduce CHD risk among genetically susceptible individuals.
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