ArticleInfection and immunity1997
Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 152 citations in OpenAlex.
- Clinical Significance of Elevated Xanthine Dehydrogenase Levels and Hyperuricemia in Patients with Sepsis.International journal of molecular sciences · 2023Article
- Salmonella Typhimurium outer membrane protein A (OmpA) renders protection from nitrosative stress of macrophages by maintaining the stability of bacterial outer membrane.PLoS pathogens · 2022Article
- Mechanisms of TLR4-Mediated Autophagy and Nitroxidative Stress.Frontiers in cellular and infection microbiology · 2021Review
- Interplay between enterohaemorrhagicEmerging microbes & infections · 2020Article
- Review
- Humoral Immunity vs.Frontiers in immunology · 2019Review
- Hoodwinking the Big-Eater to Prosper: The Salmonella-Macrophage Paradigm.Journal of innate immunity · 2019Review
- Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach.Scientific reports · 2017Article
- Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.The Journal of biological chemistry · 2016Article
- Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens.Current opinion in microbiology · 2016Review
- Article
- Role of host xanthine oxidase in infection due to enteropathogenic and Shiga-toxigenic Escherichia coli.Infection and immunity · 2013Article
- The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts.PloS one · 2012Article
- Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- Redox proteomics of protein-bound methionine oxidation.Molecular & cellular proteomics : MCP · 2011Article
- Nitric oxide and salmonella pathogenesis.Frontiers in microbiology · 2011Article
- Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar typhimurium in the inbred mouse strain SPRET/Ei.Infection and immunity · 2010Article
- A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide.Journal of clinical biochemistry and nutrition · 2010Article
- Killing of Bacillus spores is mediated by nitric oxide and nitric oxide synthase during glycoconjugate-enhanced phagocytosis.Glycoconjugate journal · 2010Article
- Resistance to peroxynitrite in Neisseria gonorrhoeae.Microbiology (Reading, England) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of superoxide anion (O2-) and nitric oxide (NO) in the host defense mechanism against Salmonella typhimurium (LT-2) was examined by focusing on xanthine oxidase (XO) as an O2(-)-generating system and on inducible NO synthase (iNOS). When ICR mice were infected with a 0.1 50% lethal dose (2 x 10(5) CFU) of S. typhimurium, bacterial growth in the liver reached a peak value 3 days after infection (10(4.32) CFU/g of liver) and decreased thereafter. XO activity in the liver became maximum at 7 days after infection; the value was 34.6 +/- 1.4 mU/g of liver at 7 days (compared with 11.0 +/- 1.3 mU/g of liver before infection). The time profile of NO production in the liver as determined by electron spin resonance spectroscopy was consistent with that of XO activity. Histological examination of infected liver showed the formation of multiple microabscesses with granulomatous lesions consisting of polymorphonuclear cells and mononuclear cells, and iNOS-expressing cells were localized in the confined areas of the microabscesses. When XO inhibitors such as allopurinol and 4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine (AHPP) were administered to the infected mice, the mortality of the mice was significantly increased (10 of 21 and 11 of 20 for the allopurinol- and AHPP-treated groups, respectively, versus 2 of 20 for control mice), and bacterial growth was significantly enhanced. A similar exacerbation of the infection was obtained with N(omega)-monomethyl-L-arginine (L-NMMA) treatment of the mice. Of considerable importance is that granuloma formation in the liver was poorly developed by treatment with either XO inhibitors or L-NMMA. These results suggest that XO and NO play an important role in the antimicrobial mechanism against S. typhimurium in mice.
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