ArticleInfection and immunity1997
Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
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Who cites it
153 citing papers in PubMed.
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- Maternal bacteremia caused byHeliyon · 2023Article
- Genomic and pathogenicity islands ofFrontiers in molecular biosciences · 2023Review
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- Novel Approaches to Environmental Monitoring and Control ofFoods (Basel, Switzerland) · 2022Review
- Prevalence and Clonal Diversity of over 1,200 Listeria monocytogenes Isolates Collected from Public Access Waters near Produce Production Areas on the Central California Coast during 2011 to 2016.Applied and environmental microbiology · 2022Article
- Sequence Variability of pXO1-Located Pathogenicity Genes ofPathogens (Basel, Switzerland) · 2021Article
- Molecular Typing ofPathogens (Basel, Switzerland) · 2021Article
- High Prevalence ofFood science of animal resources · 2021Article
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- Whole genome genetic variation and linkage disequilibrium in a diverse collection of Listeria monocytogenes isolates.PloS one · 2021Article
- Genomic-based identification of environmental and clinical Listeria monocytogenes strains associated with an abortion outbreak in beef heifers.BMC veterinary research · 2020Article
- Nevertheless, She Resisted - Role of the Environment onFrontiers in microbiology · 2020Article
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- Hypervirulent Listeria monocytogenes clones' adaption to mammalian gut accounts for their association with dairy products.Nature communications · 2019Article
- Isolation and Characterization of ClinicalFrontiers in microbiology · 2019Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
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Abstract
A total of 133 Listeria monocytogenes isolates were characterized by ribotyping and allelic analysis of the virulence genes hly, actA, and inlA to uncover linkages between independent phylogenetic and specific virulence markers. PCR-restriction fragment length polymorphisms revealed 8 hly, 11 inl4, and 2 actA alleles. The combination of these virulence gene alleles and ribotype patterns separated L. monocytogenes into three distinct lineages. While distinct hly and inlA alleles were generally found to cluster into these three lineages, actA alleles segregated independently. These three phylogenetic lineages were confirmed when 22 partial actA DNA sequences were analyzed. The clinical history of the L. monocytogenes strains showed evidence for differences in pathogenic potential among the three lineages. Lineage I contains all strains isolated during epidemic outbreaks of listeriosis, while no human isolates were found in lineage III. Animal isolates were found in all three lineages. We found evidence that isolates from lineages I and III have a higher plaquing efficiency than lineage II strains in a cell culture assay. Strains from lineage III also seem to form larger plaques than strains from lineage II. A distinctive ribotype fragment and unique 16S rRNA gene sequences furthermore suggest that lineage III might represent a L. monocytogenes subspecies. None of the 20 human isolates available but 11% of our animal isolates were grouped in this lineage, indicating that strains in this lineage might have reduced virulence for humans.
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