ArticleInfection and immunity1997
Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Hfe Permease andACS infectious diseases · 2024Article
- Manganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganisms.ACS chemical biology · 2015Review
- "Affect of anaerobiosis on the antibiotic susceptibility of H. influenzae".BMC research notes · 2013Article
- Haemophilus influenzae and oxidative stress.Frontiers in cellular and infection microbiology · 2012Review
- Genome-scale approaches to identify genes essential for Haemophilus influenzae pathogenesis.Frontiers in cellular and infection microbiology · 2012Review
- Metal uptake in host-pathogen interactions: role of iron in Porphyromonas gingivalis interactions with host organisms.Periodontology 2000 · 2010Review
- Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene.Infection and immunity · 2009Article
- The periplasmic disulfide oxidoreductase DsbA contributes to Haemophilus influenzae pathogenesis.Infection and immunity · 2008Article
- Metabolic analysis of Moraxella catarrhalis and the effect of selected in vitro growth conditions on global gene expression.Infection and immunity · 2007Article
- The ArcA regulon and oxidative stress resistance in Haemophilus influenzae.Molecular microbiology · 2007Article
- Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan.BMC microbiology · 2006Article
- Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae.Journal of bacteriology · 2003Article
- Two-component systems in Haemophilus influenzae: a regulatory role for ArcA in serum resistance.Infection and immunity · 2003Article
- The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci.Journal of bacteriology · 2002Article
- Inactivation of the Moraxella catarrhalis superoxide dismutase SodA induces constitutive expression of iron-repressible outer membrane proteins.Infection and immunity · 2002Article
- ohr, Encoding an organic hydroperoxide reductase, is an in vivo-induced gene in Actinobacillus pleuropneumoniae.Infection and immunity · 2002Article
- Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.Infection and immunity · 2000Article
- Characterization of the major superoxide dismutase of Staphylococcus aureus and its role in starvation survival, stress resistance, and pathogenicity.Journal of bacteriology · 1999Article
- Periplasmic superoxide dismutase in meningococcal pathogenicity.Infection and immunity · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Haemophilus influenzae type b, a causative agent of bacterial sepsis and meningitis in young children, contains a single superoxide dismutase (SOD), a cytoplasmic MnSOD. To study the role of this enzyme, a chromosomal sodA::lacZ mutant (M-2) was constructed. M-2 had an increased sensitivity towards oxygen and the redox-active agent paraquat. A 3.4-fold increase in sodA-lacZ expression was found in M-2 grown with oxygen supply rates between 3 and 36 mmol of O2/liter/h. In similar experiments with the wild type, assaying SodA activity, a 3.1-fold increase was found. Both the wild type and M-2 grew best at the lowest oxygen supply rate tested, consistent with the notion that H. influenzae prefers a more anaerobic environment. In the infant rat model of infection, the ability of M-2 to colonize the nasopharynx was found to be impaired, but its ability to cause invasive disease was unaffected. This suggests that after invasion, the growth disadvantage imposed by a SodA- phenotype is not limiting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.