ArticleInfection and immunity1997
Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults.The Journal of nutrition · 2012Trial
- Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans.Infection and immunity · 2002Trial
- Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77.Biomedicines · 2022Article
- Multiple aspects of lymphatic dysfunction in anFrontiers in physiology · 2022Article
- Review
- A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.The Journal of infectious diseases · 2019Article
- Evaluating All Potential Oral Complications of Diabetes Mellitus.Frontiers in endocrinology · 2019Review
- Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia.Frontiers in immunology · 2019Article
- Effects of dyslipidaemia on monocyte production and function in cardiovascular disease.Nature reviews. Cardiology · 2017Review
- Collagen-like proteins of pathogenic streptococci.Molecular microbiology · 2017Review
- Very-low and low-density lipoproteins induce neutral lipid accumulation and impair migration in monocyte subsets.Scientific reports · 2016Article
- Immunomodulatory effects of aerobic training in obesity.Mediators of inflammation · 2011Article
- Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration.The American journal of pathology · 2009Article
- CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.Circulation research · 2008Article
- Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity.The Journal of experimental medicine · 2007Article
- Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients - A Preliminary Case-Controlled Study.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested the use of lipoproteins as an adjuvant treatment of lethal gram-negative infections. However, other important microorganisms for the etiology of sepsis, such as Candida species, grow better in lipid-rich environments. We investigated the effect of hyperlipoproteinemia on systemic candidiasis in low-density-lipoprotein-receptor-deficient (LDLR-/-) mice, in which the loss of the receptor results in a seven- to ninefold-higher plasma LDL level than that in their wild-type littermates (C57BL/6J). LDLR-/- mice died earlier, and the outgrowth of Candida albicans in the kidneys and livers of LDLR-/- mice was significantly higher compared with that of controls. After infection, circulating cytokine concentrations were significantly higher in LDLR-/- mice. In vitro, C. albicans grew better in plasma samples of LDLR-/- mice than in control plasma samples and peritoneal macrophages of LDLR-/- mice challenged with heat-killed C. albicans produced more cytokines than did those of controls. This latter phenomenon was probably due to increased binding of yeast cells to macrophages of LDLR-/- mice. These data suggest that hyperlipoproteinemia is deleterious in systemic candidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.