ArticleMolecular and cellular biology1997
Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- Physiological and pathological roles of lipogenesis.Nature metabolism · 2023Review
- Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.Nature communications · 2015Article
- Nuclear receptors and their selective pharmacologic modulators.Pharmacological reviews · 2013Review
- Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.PloS one · 2012Article
- Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?Molecular neurodegeneration · 2010Article
- Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation.Respiratory research · 2010Article
- Minireview: liver X receptor beta: emerging roles in physiology and diseases.Molecular endocrinology (Baltimore, Md.) · 2009Review
- Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.Molecular and cellular biology · 2004Article
- Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.Molecular and cellular biology · 2001Article
- Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Dominant activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor alpha-beta heterodimeric complex.Molecular and cellular biology · 1999Article
- Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2.Molecular and cellular biology · 1998Article
- Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function.Molecular and cellular biology · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OR1 is a member of the steroid/thyroid hormone nuclear receptor superfamily which has been described to mediate transcriptional responses to retinoids and oxysterols. On a DR4 response element, an OR1 heterodimer with the nuclear receptor retinoid X receptor alpha (RXR alpha) has been described to convey transcriptional activation in both the absence and presence of the RXR ligand 9-cis retinoic acid, the mechanisms of which have remained unclear. Here, we dissect the effects of RXR alpha and OR1 ligand-binding domain interaction on transcriptional regulation and the role of the respective carboxy-terminal activation domains (AF-2s) in the absence and presence of the RXR ligand, employing chimeras of the nuclear receptors containing the heterologous GAL4 DNA-binding domain as well as natural receptors. The results show that the interaction of the RXR and OR1 ligand-binding domains unleashes a transcription activation potential that is mainly dependent on the AF-2 of OR1, indicating that interaction with RXR activates OR1. This defines dimerization-induced activation as a novel function of heterodimeric interaction and mechanism of receptor activation not previously described for nuclear receptors. Moreover, we present evidence that activation of OR1 occurs by a conformational change induced upon heterodimerization with RXR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.