ArticleMolecular and cellular biology1997
Transcription reinitiation rate: a special role for the TATA box.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates.Nature communications · 2025Article
- Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription.Nature genetics · 2024Article
- Article
- TATA and paused promoters active in differentiated tissues have distinct expression characteristics.Molecular systems biology · 2021Article
- Article
- Promoter-specific dynamics of TATA-binding protein association with the human genome.Genome research · 2019Article
- Linking Core Promoter Classes to Circadian Transcription.PLoS genetics · 2016Article
- A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting.Nature communications · 2016Article
- DNA signals at isoform promoters.Scientific reports · 2016Article
- DTIE, a novel core promoter element that directs start site selection in TATA-less genes.Nucleic acids research · 2016Article
- Affinity and competition for TBP are molecular determinants of gene expression noise.Nature communications · 2016Article
- Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism.PLoS computational biology · 2015Article
- Co-occurrence of transcription and translation gene regulatory features underlies coordinated mRNA and protein synthesis.BMC genomics · 2014Article
- Investigating transcription reinitiation through in vitro approaches.Transcription · 2014Review
- A global change in RNA polymerase II pausing during the Drosophila midblastula transition.eLife · 2013Article
- Sequence features of yeast and human core promoters that are predictive of maximal promoter activity.Nucleic acids research · 2013Article
- Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression.PLoS computational biology · 2013Article
- A genomic model of condition-specific nucleosome behavior explains transcriptional activity in yeast.Genome research · 2012Article
- Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster.Gene regulation and systems biology · 2012Article
- Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?Chromosoma · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Promoters need to specify both the timing of transcriptional induction and the amount of transcript synthesized. In order to explore each of these effects separately, in vitro assays for the level of active preinitiation complex formation and for the rate of continuous RNA production were done. The effects were found to be influenced differently by different promoter elements. A consensus TATA element had a very strong effect on the rate of continuous RNA production, whereas two types of activators were important primarily in forming active transcription preinitiation complexes. Consensus TATA promoters exhibited high rates of continuous transcription; they assembled active preinitiation transcription complexes slowly but then produced transcripts continuously at an approximately fivefold-higher rate. Initiator-containing TATA-less promoters produced continuous transcripts slowly. Point mutations in the TATA element led to lower levels of transcription by reducing the number of preinitiation complexes and amplifying this reduction by lowering the apparent reinitiation rate. The results allow understanding of the sequence diversity of promoter elements in terms of specifying separate controls over the sensitivity of gene induction and over the strength of the induced promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.