ArticleMolecular and cellular biology1997
Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies.Journal of molecular biology · 2024Review
- Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway.Drug design, development and therapy · 2021Article
- Seven-Gene Signature Based on Glycolysis Is Closely Related to the Prognosis and Tumor Immune Infiltration of Patients With Gastric Cancer.Frontiers in oncology · 2020Article
- ZBTB7A governs estrogen receptor alpha expression in breast cancer.Journal of molecular cell biology · 2018Article
- FBI-1 mRNA in normal mucosa is an independent prognostic factor in colorectal cancer patients.International journal of clinical and experimental pathology · 2018Article
- Regulation of hematopoietic development by ZBTB transcription factors.International journal of hematology · 2016Review
- Article
- LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.Nature communications · 2015Article
- ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.Molecular cancer research : MCR · 2015Article
- EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation.International journal of molecular sciences · 2014Article
- ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.Genes & development · 2014Article
- Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene.The Journal of biological chemistry · 2014Article
- p38β, A novel regulatory target of Pokemon in hepatic cells.International journal of molecular sciences · 2013Article
- Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.The Journal of biological chemistry · 2013Article
- Homeostatic regulatory role of Pokemon in NF-κB signaling: stimulating both p65 and IκBα expression in human hepatocellular carcinoma cells.Molecular and cellular biochemistry · 2013Article
- Knock-down of Kaiso induces proliferation and blocks granulocytic differentiation in blast crisis of chronic myeloid leukemia.Cancer cell international · 2012Article
- POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.Immunological reviews · 2012Review
- Nuclear speckles.Cold Spring Harbor perspectives in biology · 2011Review
- Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers.Molecular cancer · 2010Article
- Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells.Cellular & molecular biology letters · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The human immunodeficiency virus (HIV-1) promoter directs the synthesis of two classes of RNA molecules, short transcripts and full-length transcripts. The synthesis of short transcripts depends on a bipartite DNA element, the inducer of short transcripts (IST), located in large part downstream of the HIV-1 start site of transcription. IST does not require any viral product for function and is thought to direct the assembly of transcription complexes that are incapable of efficient elongation. Nothing is known, however, about the biochemical mechanisms that mediate IST function. Here, we report the identification and purification of a factor that binds specifically to the IST. This factor, FBI-1, recognizes a large bipartite binding site that coincides with the bipartite IST element. It is constituted at least in part by an 86-kDa polypeptide that can be specifically cross-linked to IST. FBI-1 also binds to promoter and attenuation regions of a number of cellular and viral transcription units that are regulated by a transcription elongation block. This observation, together with the observation that the binding of FBI-1 to IST mutants correlates with the ability of these mutants to direct IST function, suggests that FBI-1 may be involved in the establishment of abortive transcription complexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.