ArticleMolecular and cellular biology1997
Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 69 citations in OpenAlex.
- The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model.Chemical research in toxicology · 2020Review
- AhR signaling pathways and regulatory functions.Biochimie open · 2018Review
- The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.Cellular and molecular life sciences : CMLS · 2016Review
- The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Archives of biochemistry and biophysics · 2013Article
- Article
- The mouse and human Ah receptor differ in recognition of LXXLL motifs.Archives of biochemistry and biophysics · 2008Article
- Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.Toxicology and applied pharmacology · 2008Article
- Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio).Environmental health perspectives · 2001Article
- Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.Molecular and cellular biology · 2000Review
- Contributions to gene activation by multiple functions of Bicoid.The Biochemical journal · 1999Article
- Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential.Gene expression · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have studied the transcriptional regulation of the dioxin-inducible mouse CYP1A1 gene in its native chromosomal setting. We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cells. Our data reveal that transactivation domains in AhR's C-terminal half mediate occupancy of the nuclear factor 1 site and TATA box for the CYP1A1 promoter in vivo. Transactivation domains of VP16 and AhR nuclear translocator, but not Sp1, can substitute for AhR's C-terminal half in facilitating protein binding at the promoter. Our data also reveal an apparent linear relationship between promoter occupancy and CYP1A1 gene expression in chromatin. These findings provide new insights into the in vivo mechanism of transcriptional activation for an interesting mammalian gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.